Names & Taxonomy
- Uniprot ID:
- P07711
- Entry Name:
- CATL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain]
- Gene Names:
- CTSL CTSL1
- Gene Names Primary:
- CTSL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 333
- Sequence:
- MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Important for the overall degradation of proteins in lysosomes.
- Catalytic Activity:
- Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
- Active Site:
- ACT_SITE 138 138; ACT_SITE 276 276; ACT_SITE 300 300
- Gene Ontology Go:
- endolysosome lumen
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
nucleus
collagen binding
cysteine-type endopeptidase activity
cysteine-type peptidase activity
fibronectin binding
histone binding
proteoglycan binding
serpin family protein binding
adaptive immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
cellular response to thyroid hormone stimulus
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
innate immune response
macrophage apoptotic process
proteolysis
proteolysis involved in cellular protein catabolic process
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- adaptive immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
cellular response to thyroid hormone stimulus
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
innate immune response
macrophage apoptotic process
proteolysis
proteolysis involved in cellular protein catabolic process
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- collagen binding
cysteine-type endopeptidase activity
cysteine-type peptidase activity
fibronectin binding
histone binding
proteoglycan binding
serpin family protein binding - Gene Ontology Cellular Component:
- endolysosome lumen
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
nucleus - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Protease
Reference proteome
Signal
Thiol protease
Zymogen - Interacts With:
- O43765; G5EFH4