Names & Taxonomy
- Uniprot ID:
- P07478
- Entry Name:
- TRY2_HUMAN
- Status:
- reviewed
- Protein Names:
- Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II)
- Gene Names:
- PRSS2 TRY2 TRYP2
- Gene Names Primary:
- PRSS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 247
- Sequence:
- MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- In the ileum, may be involved in defensin processing, including DEFA5.
- Catalytic Activity:
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 63 63 Charge relay system.
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- extracellular matrix
extracellular region
extracellular space
calcium ion binding
serine-type endopeptidase activity
collagen catabolic process
digestion
extracellular matrix disassembly
extracellular matrix organization
innate immune response
positive regulation of cell adhesion
positive regulation of cell growth
proteolysis - Gene Ontology Biological Process:
- collagen catabolic process
digestion
extracellular matrix disassembly
extracellular matrix organization
innate immune response
positive regulation of cell adhesion
positive regulation of cell growth
proteolysis - Gene Ontology Molecular Function:
- calcium ion binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular matrix
extracellular region
extracellular space - Keywords:
- Calcium
Complete proteome
Digestion
Direct protein sequencing
Disulfide bond
Hydrolase
Metal-binding
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen