Names & Taxonomy
- Uniprot ID:
- P07437
- Entry Name:
- TBB5_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin beta chain (Tubulin beta-5 chain)
- Gene Names:
- TUBB TUBB5 OK/SW-cl.56
- Gene Names Orf:
- OK/SW-cl.56
- Gene Names Primary:
- TUBB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 444
- Sequence:
- MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Cross Reference Drug Bank:
- DB01394 DB01179 DB00570 DB00541 DB00361
- Gene Ontology Go:
- cell body
cytoplasmic ribonucleoprotein granule
cytoskeleton
extracellular exosome
extracellular region
microtubule
nuclear envelope lumen
nucleus
protein complex
GTP binding
GTPase activity
MHC class I protein binding
structural constituent of cytoskeleton
structural molecule activity
ubiquitin protein ligase binding
cell division
cellular process
cytoskeleton-dependent intracellular transport
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
movement of cell or subcellular component
natural killer cell mediated cytotoxicity
organelle organization
spindle assembly - Gene Ontology Biological Process:
- cell division
cellular process
cytoskeleton-dependent intracellular transport
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
movement of cell or subcellular component
natural killer cell mediated cytotoxicity
organelle organization
spindle assembly - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
MHC class I protein binding
structural constituent of cytoskeleton
structural molecule activity
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cell body
cytoplasmic ribonucleoprotein granule
cytoskeleton
extracellular exosome
extracellular region
microtubule
nuclear envelope lumen
nucleus
protein complex - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Methylation
Microtubule
Nucleotide-binding
Phosphoprotein
Reference proteome
Ubl conjugation - Interacts With:
- Q8AZK7; P05412; Q5S007; Q9BSI4