Names & Taxonomy
- Uniprot ID:
- P07355
- Entry Name:
- ANXA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
- Gene Names:
- ANXA2 ANX2 ANX2L4 CAL1H LPC2D
- Gene Names Primary:
- ANXA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 339
- Sequence:
- MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix, basement membrane
Function
- Function:
- Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
- Cross Reference Drug Bank:
- DB00031
- Gene Ontology Go:
- basement membrane
basolateral plasma membrane
cell cortex
cell surface
cytosol
early endosome
endosome
extracellular exosome
extracellular space
extrinsic component of plasma membrane
late endosome membrane
lipid particle
lysosomal membrane
macropinosome
melanosome
membrane
midbody
myelin sheath adaxonal region
nucleus
PCSK9-AnxA2 complex
perinuclear region of cytoplasm
plasma membrane
ruffle
sarcolemma
Schmidt-Lanterman incisure
vesicle
calcium ion binding
calcium-dependent phospholipid binding
calcium-dependent protein binding
phosphatidylinositol-4,5-bisphosphate binding
phospholipase A2 inhibitor activity
poly(A) RNA binding
protease binding
S100 protein binding
angiogenesis
body fluid secretion
collagen fibril organization
fibrinolysis
membrane budding
membrane raft assembly
muscle contraction
negative regulation of catalytic activity
negative regulation of low-density lipoprotein particle receptor catabolic process
negative regulation of receptor binding
negative regulation of receptor internalization
osteoclast development
positive regulation of binding
positive regulation of fibroblast proliferation
positive regulation of protein phosphorylation
positive regulation of receptor activity
positive regulation of vesicle fusion
protein heterotetramerization
protein targeting to plasma membrane
response to thyroid hormone - Gene Ontology Biological Process:
- angiogenesis
body fluid secretion
collagen fibril organization
fibrinolysis
membrane budding
membrane raft assembly
muscle contraction
negative regulation of catalytic activity
negative regulation of low-density lipoprotein particle receptor catabolic process
negative regulation of receptor binding
negative regulation of receptor internalization
osteoclast development
positive regulation of binding
positive regulation of fibroblast proliferation
positive regulation of protein phosphorylation
positive regulation of receptor activity
positive regulation of vesicle fusion
protein heterotetramerization
protein targeting to plasma membrane
response to thyroid hormone - Gene Ontology Molecular Function:
- calcium-dependent phospholipid binding
calcium-dependent protein binding
calcium ion binding
phosphatidylinositol-4,5-bisphosphate binding
phospholipase A2 inhibitor activity
poly(A) RNA binding
protease binding
S100 protein binding - Gene Ontology Cellular Component:
- basement membrane
basolateral plasma membrane
cell cortex
cell surface
cytosol
early endosome
endosome
extracellular exosome
extracellular space
extrinsic component of plasma membrane
late endosome membrane
lipid particle
lysosomal membrane
macropinosome
melanosome
membrane
midbody
myelin sheath adaxonal region
nucleus
PCSK9-AnxA2 complex
perinuclear region of cytoplasm
plasma membrane
ruffle
sarcolemma
Schmidt-Lanterman incisure
vesicle - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Annexin
Basement membrane
Calcium
Calcium/phospholipid-binding
Complete proteome
Direct protein sequencing
Extracellular matrix
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat
Secreted
Ubl conjugation - Interacts With:
- Q99IB8; P40692; Q8NBP7; Q9NUX5