Names & Taxonomy

Uniprot ID:
P07339
Entry Name:
CATD_HUMAN
Status:
reviewed
Protein Names:
Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]
Gene Names:
CTSD CPSD
Gene Names Primary:
CTSD
Organism:
Homo sapiens (Human)

Structure

Length:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).

Function

Function:
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Catalytic Activity:
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
Active Site:
ACT_SITE 97 97
Cross Reference Drug Bank:
DB00030
Gene Ontology Go:
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
melanosome
membrane raft
aspartic-type endopeptidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class II
autophagy
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
protein catabolic process
Gene Ontology Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class II
autophagy
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
protein catabolic process
Gene Ontology Molecular Function:
aspartic-type endopeptidase activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
melanosome
membrane raft
Keywords:
3D-structure
Alzheimer disease
Aspartyl protease
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Neurodegeneration
Neuronal ceroid lipofuscinosis
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zymogen
Interacts With:
P05067

Publication

PubMed ID:
3927292 3588310 2069717 15489334 8262386 7935485 12643545 12754519 16335952 16670177 17081065 16263699 19159218 20551380 21269460 23234360 24275569 25944712 8467789 8393577 10716266 16685649 21990111