Names & Taxonomy
- Uniprot ID:
- P07339
- Entry Name:
- CATD_HUMAN
- Status:
- reviewed
- Protein Names:
- Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]
- Gene Names:
- CTSD CPSD
- Gene Names Primary:
- CTSD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 412
- Sequence:
- MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
Function
- Function:
- Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
- Catalytic Activity:
- Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
- Active Site:
- ACT_SITE 97 97
- Cross Reference Drug Bank:
- DB00030
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
melanosome
membrane raft
aspartic-type endopeptidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class II
autophagy
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
protein catabolic process - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
autophagy
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
protein catabolic process - Gene Ontology Molecular Function:
- aspartic-type endopeptidase activity
- Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
melanosome
membrane raft - Keywords:
- 3D-structure
Alzheimer disease
Aspartyl protease
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Neurodegeneration
Neuronal ceroid lipofuscinosis
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zymogen - Interacts With:
- P05067