Names & Taxonomy
- Uniprot ID:
- P07307
- Entry Name:
- ASGR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)
- Gene Names:
- ASGR2 CLEC4H2
- Gene Names Primary:
- ASGR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 311
- Sequence:
- MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVCEKRRNATGEVA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type II membrane protein.
Function
- Function:
- Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
- Cross Reference Drug Bank:
- DB00025
- Gene Ontology Go:
- integral component of membrane
asialoglycoprotein receptor activity
carbohydrate binding
bone mineralization
cell surface receptor signaling pathway
glycoprotein metabolic process
lipid homeostasis
receptor-mediated endocytosis
regulation of protein stability - Gene Ontology Biological Process:
- bone mineralization
cell surface receptor signaling pathway
glycoprotein metabolic process
lipid homeostasis
receptor-mediated endocytosis
regulation of protein stability - Gene Ontology Molecular Function:
- asialoglycoprotein receptor activity
carbohydrate binding - Gene Ontology Cellular Component:
- integral component of membrane
- Keywords:
- Alternative splicing
Calcium
Complete proteome
Disulfide bond
Endocytosis
Glycoprotein
Lectin
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix - Interacts With:
- Q96G23