Names & Taxonomy
- Uniprot ID:
- P07225
- Entry Name:
- PROS_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin K-dependent protein S
- Gene Names:
- PROS1 PROS
- Gene Names Primary:
- PROS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 676
- Sequence:
- MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
- Cross Reference Drug Bank:
- DB00055 DB00170 DB00464
- Gene Ontology Go:
- blood microparticle
endoplasmic reticulum membrane
extracellular exosome
extracellular region
extracellular space
Golgi lumen
Golgi membrane
plasma membrane
platelet alpha granule lumen
protein complex
calcium ion binding
endopeptidase inhibitor activity
blood coagulation
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
fibrinolysis
innate immune response
leukocyte migration
negative regulation of endopeptidase activity
peptidyl-glutamic acid carboxylation
platelet activation
platelet degranulation
positive regulation of phagocytosis
post-translational protein modification
regulation of complement activation
response to lipopolysaccharide
signal peptide processing - Gene Ontology Biological Process:
- blood coagulation
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
fibrinolysis
innate immune response
leukocyte migration
negative regulation of endopeptidase activity
peptidyl-glutamic acid carboxylation
platelet activation
platelet degranulation
positive regulation of phagocytosis
post-translational protein modification
regulation of complement activation
response to lipopolysaccharide
signal peptide processing - Gene Ontology Molecular Function:
- calcium ion binding
endopeptidase inhibitor activity - Gene Ontology Cellular Component:
- blood microparticle
endoplasmic reticulum membrane
extracellular exosome
extracellular region
extracellular space
Golgi lumen
Golgi membrane
plasma membrane
platelet alpha granule lumen
protein complex - Keywords:
- 3D-structure
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Disulfide bond
EGF-like domain
Fibrinolysis
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Thrombophilia
Zymogen
Publication
- PubMed ID:
- 2820795 3467362 2148110 2148111 14702039 15489334 2944113 7482398 16335952 24275569 15952784 2143091 8298131 7803790 7545463 7579449 8977443 8639833 8781426 8943854 8765219 8701404 9031443 9241758 10447256 10613647 10706858 10790208 11372770 11776305 12351389 11858485 11927129 12632031 15238143 15712227 16959974 20484936