Names & Taxonomy
- Uniprot ID:
- P07148
- Entry Name:
- FABPL_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP)
- Gene Names:
- FABP1 FABPL
- Gene Names Primary:
- FABP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 127
- Sequence:
- MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVFKRISKRI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
- Cross Reference Drug Bank:
- DB02659 DB04224
- Gene Ontology Go:
- apical cortex
cytoplasm
cytosol
extracellular exosome
nucleoplasm
peroxisomal matrix
antioxidant activity
bile acid binding
chromatin binding
drug binding
fatty acid binding
long-chain fatty acid transporter activity
phospholipid binding
cellular lipid metabolic process
cellular oxidant detoxification
cellular response to hydrogen peroxide
cellular response to hypoxia
intestinal absorption
mitophagy in response to mitochondrial depolarization
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell proliferation
positive regulation of defense response to virus by host
positive regulation of fatty acid beta-oxidation
positive regulation of hydrolase activity
small molecule metabolic process
triglyceride catabolic process
xenophagy - Gene Ontology Biological Process:
- cellular lipid metabolic process
cellular oxidant detoxification
cellular response to hydrogen peroxide
cellular response to hypoxia
intestinal absorption
mitophagy in response to mitochondrial depolarization
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell proliferation
positive regulation of defense response to virus by host
positive regulation of fatty acid beta-oxidation
positive regulation of hydrolase activity
small molecule metabolic process
triglyceride catabolic process
xenophagy - Gene Ontology Molecular Function:
- antioxidant activity
bile acid binding
chromatin binding
drug binding
fatty acid binding
long-chain fatty acid transporter activity
phospholipid binding - Gene Ontology Cellular Component:
- apical cortex
cytoplasm
cytosol
extracellular exosome
nucleoplasm
peroxisomal matrix - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Lipid-binding
Phosphoprotein
Polymorphism
Reference proteome
Transport - Interacts With:
- P21333-2