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Names & Taxonomy

Uniprot ID:: P07101
Entry Name:: TY3H_HUMAN
Status:: reviewed
Protein Names:: Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)
Gene Names:: TH TYH
Gene Names Primary:: TH
Organism:: Homo sapiens (Human)

Structure

Length:: 528
Sequence:: MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
Proteomes:: UP000005640

Function

Function:: Plays an important role in the physiology of adrenergic neurons.
Pathway:: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
Catalytic Activity:: L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin.
Cofactor:: COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
Enzyme Regulation:: ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity.
Cross Reference Drug Bank:: DB00120 DB00135 DB00765 DB00360
Gene Ontology Go:: cytoplasm
cytoplasmic side of plasma membrane
cytoplasmic vesicle
cytosol
dendrite
melanosome membrane
mitochondrion
neuron projection
nucleus
perikaryon
smooth endoplasmic reticulum
synaptic vesicle
terminal bouton
amino acid binding
dopamine binding
enzyme binding
ferric iron binding
ferrous iron binding
oxygen binding
tetrahydrobiopterin binding
tyrosine 3-monooxygenase activity
aminergic neurotransmitter loading into synaptic vesicle
anatomical structure morphogenesis
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
cellular response to drug
cellular response to glucose stimulus
cellular response to growth factor stimulus
cellular response to manganese ion
cellular response to nicotine
cerebral cortex development
circadian sleep/wake cycle
dopamine biosynthetic process
dopamine biosynthetic process from tyrosine
eating behavior
embryonic camera-type eye morphogenesis
epinephrine biosynthetic process
eye photoreceptor cell development
fatty acid metabolic process
glycoside metabolic process
heart development
heart morphogenesis
isoquinoline alkaloid metabolic process
learning
locomotory behavior
mating behavior
memory
multicellular organism aging
neurotransmitter biosynthetic process
norepinephrine biosynthetic process
organ morphogenesis
phthalate metabolic process
phytoalexin metabolic process
pigmentation
regulation of heart contraction
response to activity
response to amphetamine
response to corticosterone
response to electrical stimulus
response to estradiol
response to ethanol
response to ether
response to herbicide
response to hypoxia
response to immobilization stress
response to isolation stress
response to light stimulus
response to lipopolysaccharide
response to nutrient levels
response to peptide hormone
response to pyrethroid
response to salt stress
response to water deprivation
response to zinc ion
sensory perception of sound
small molecule metabolic process
social behavior
sphingolipid metabolic process
synaptic transmission, dopaminergic
terpene metabolic process
visual perception
Gene Ontology Biological Process:: aminergic neurotransmitter loading into synaptic vesicle
anatomical structure morphogenesis
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
cellular response to drug
cellular response to glucose stimulus
cellular response to growth factor stimulus
cellular response to manganese ion
cellular response to nicotine
cerebral cortex development
circadian sleep/wake cycle
dopamine biosynthetic process
dopamine biosynthetic process from tyrosine
eating behavior
embryonic camera-type eye morphogenesis
epinephrine biosynthetic process
eye photoreceptor cell development
fatty acid metabolic process
glycoside metabolic process
heart development
heart morphogenesis
isoquinoline alkaloid metabolic process
learning
locomotory behavior
mating behavior
memory
multicellular organism aging
neurotransmitter biosynthetic process
norepinephrine biosynthetic process
organ morphogenesis
phthalate metabolic process
phytoalexin metabolic process
pigmentation
regulation of heart contraction
response to activity
response to amphetamine
response to corticosterone
response to electrical stimulus
response to estradiol
response to ethanol
response to ether
response to herbicide
response to hypoxia
response to immobilization stress
response to isolation stress
response to light stimulus
response to lipopolysaccharide
response to nutrient levels
response to peptide hormone
response to pyrethroid
response to salt stress
response to water deprivation
response to zinc ion
sensory perception of sound
small molecule metabolic process
social behavior
sphingolipid metabolic process
synaptic transmission, dopaminergic
terpene metabolic process
visual perception
Gene Ontology Molecular Function:: amino acid binding
dopamine binding
enzyme binding
ferric iron binding
ferrous iron binding
oxygen binding
tetrahydrobiopterin binding
tyrosine 3-monooxygenase activity
Gene Ontology Cellular Component:: cytoplasm
cytoplasmic side of plasma membrane
cytoplasmic vesicle
cytosol
dendrite
melanosome membrane
mitochondrion
neuron projection
nucleus
perikaryon
smooth endoplasmic reticulum
synaptic vesicle
terminal bouton
Keywords:: 3D-structure
Alternative splicing
Catecholamine biosynthesis
Complete proteome
Disease mutation
Dystonia
Iron
Metal-binding
Monooxygenase
Neurotransmitter biosynthesis
Oxidoreductase
Parkinson disease
Parkinsonism
Phosphoprotein
Polymorphism
Reference proteome

Names & Taxonomy

Structure

Function

Publication