Names & Taxonomy
- Uniprot ID:
- P06850
- Entry Name:
- CRF_HUMAN
- Status:
- reviewed
- Protein Names:
- Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone)
- Gene Names:
- CRH
- Gene Names Primary:
- CRH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 196
- Sequence:
- MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
- Cross Reference Drug Bank:
- DB01285
- Gene Ontology Go:
- cytoplasm
extracellular region
extracellular space
perikaryon
varicosity
hormone activity
neuropeptide hormone activity
receptor binding
adrenal gland development
associative learning
cellular response to cocaine
cellular response to dexamethasone stimulus
diterpenoid metabolic process
female pregnancy
glucocorticoid biosynthetic process
hormone-mediated apoptotic signaling pathway
hypothalamus development
inflammatory response
ion homeostasis
learning or memory
locomotory exploration behavior
long-term synaptic potentiation
lung development
negative regulation of blood pressure
negative regulation of cell death
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of epinephrine secretion
negative regulation of gene expression
negative regulation of glucagon secretion
negative regulation of luteinizing hormone secretion
negative regulation of norepinephrine secretion
parturition
positive regulation of behavioral fear response
positive regulation of calcium ion import
positive regulation of cAMP biosynthetic process
positive regulation of cell death
positive regulation of cell proliferation
positive regulation of circadian sleep/wake cycle, wakefulness
positive regulation of corticosterone secretion
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
positive regulation of digestive system process
positive regulation of gene expression
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of protein phosphorylation
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of serotonin secretion
response to corticosterone
response to drug
response to estrogen
response to ethanol
response to ether
response to immobilization stress
response to pain
signal transduction
synaptic transmission
synaptic transmission, dopaminergic - Gene Ontology Biological Process:
- adrenal gland development
associative learning
cellular response to cocaine
cellular response to dexamethasone stimulus
diterpenoid metabolic process
female pregnancy
glucocorticoid biosynthetic process
hormone-mediated apoptotic signaling pathway
hypothalamus development
inflammatory response
ion homeostasis
learning or memory
locomotory exploration behavior
long-term synaptic potentiation
lung development
negative regulation of blood pressure
negative regulation of cell death
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of epinephrine secretion
negative regulation of gene expression
negative regulation of glucagon secretion
negative regulation of luteinizing hormone secretion
negative regulation of norepinephrine secretion
parturition
positive regulation of behavioral fear response
positive regulation of calcium ion import
positive regulation of cAMP biosynthetic process
positive regulation of cell death
positive regulation of cell proliferation
positive regulation of circadian sleep/wake cycle, wakefulness
positive regulation of corticosterone secretion
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
positive regulation of digestive system process
positive regulation of gene expression
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of protein phosphorylation
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of serotonin secretion
response to corticosterone
response to drug
response to estrogen
response to ethanol
response to ether
response to immobilization stress
response to pain
signal transduction
synaptic transmission
synaptic transmission, dopaminergic - Gene Ontology Molecular Function:
- hormone activity
neuropeptide hormone activity
receptor binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular region
extracellular space
perikaryon
varicosity - Keywords:
- 3D-structure
Amidation
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Hormone
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- P34998; Q15323