Names & Taxonomy
- Uniprot ID:
- P06756
- Entry Name:
- ITAV_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin alpha-V (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
- Gene Names:
- ITGAV MSK8 VNRA
- Gene Names Primary:
- ITGAV
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1048
- Sequence:
- MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C (PubMed:20615244). Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 (PubMed:9426447, PubMed:15194773, PubMed:7519807). Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 (PubMed:24367260). Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for West nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).
- Cross Reference Drug Bank:
- DB00098
- Gene Ontology Go:
- alphav-beta3 integrin-IGF-1-IGF1R complex
cell surface
external side of plasma membrane
extracellular exosome
filopodium membrane
focal adhesion
integral component of plasma membrane
integrin alphav-beta3 complex
integrin alphav-beta5 complex
integrin alphav-beta8 complex
integrin complex
lamellipodium membrane
membrane
microvillus membrane
phagocytic vesicle
plasma membrane
ruffle membrane
extracellular matrix binding
extracellular matrix protein binding
fibronectin binding
metal ion binding
protease binding
transforming growth factor beta binding
virus receptor activity
voltage-gated calcium channel activity
angiogenesis
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
apolipoprotein A-I-mediated signaling pathway
apoptotic cell clearance
axon guidance
blood coagulation
calcium ion transmembrane transport
cell adhesion
cell growth
cell migration
cell-matrix adhesion
cell-substrate adhesion
endodermal cell differentiation
entry of symbiont into host cell by promotion of host phagocytosis
ERK1 and ERK2 cascade
extracellular matrix organization
extrinsic apoptotic signaling pathway in absence of ligand
heterotypic cell-cell adhesion
integrin-mediated signaling pathway
leukocyte migration
negative chemotaxis
negative regulation of entry of bacterium into host cell
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of lipid storage
negative regulation of lipid transport
negative regulation of lipoprotein metabolic process
negative regulation of low-density lipoprotein particle receptor biosynthetic process
negative regulation of macrophage derived foam cell differentiation
positive regulation of cell adhesion
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of osteoblast proliferation
regulation of apoptotic cell clearance
regulation of phagocytosis
substrate adhesion-dependent cell spreading
vascular endothelial growth factor receptor signaling pathway
viral entry into host cell - Gene Ontology Biological Process:
- angiogenesis
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
apolipoprotein A-I-mediated signaling pathway
apoptotic cell clearance
axon guidance
blood coagulation
calcium ion transmembrane transport
cell adhesion
cell growth
cell-matrix adhesion
cell migration
cell-substrate adhesion
endodermal cell differentiation
entry of symbiont into host cell by promotion of host phagocytosis
ERK1 and ERK2 cascade
extracellular matrix organization
extrinsic apoptotic signaling pathway in absence of ligand
heterotypic cell-cell adhesion
integrin-mediated signaling pathway
leukocyte migration
negative chemotaxis
negative regulation of entry of bacterium into host cell
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of lipid storage
negative regulation of lipid transport
negative regulation of lipoprotein metabolic process
negative regulation of low-density lipoprotein particle receptor biosynthetic process
negative regulation of macrophage derived foam cell differentiation
positive regulation of cell adhesion
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of osteoblast proliferation
regulation of apoptotic cell clearance
regulation of phagocytosis
substrate adhesion-dependent cell spreading
vascular endothelial growth factor receptor signaling pathway
viral entry into host cell - Gene Ontology Molecular Function:
- extracellular matrix binding
extracellular matrix protein binding
fibronectin binding
metal ion binding
protease binding
transforming growth factor beta binding
virus receptor activity
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- alphav-beta3 integrin-IGF-1-IGF1R complex
cell surface
external side of plasma membrane
extracellular exosome
filopodium membrane
focal adhesion
integral component of plasma membrane
integrin alphav-beta3 complex
integrin alphav-beta5 complex
integrin alphav-beta8 complex
integrin complex
lamellipodium membrane
membrane
microvillus membrane
phagocytic vesicle
plasma membrane
ruffle membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P05106; P18084