Names & Taxonomy
- Uniprot ID:
- P06737
- Entry Name:
- PYGL_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycogen phosphorylase, liver form (EC 2.4.1.1)
- Gene Names:
- PYGL
- Gene Names Primary:
- PYGL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 847
- Sequence:
- MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
- Proteomes:
- UP000005640
Function
- Function:
- Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
- Catalytic Activity:
- ((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Enzyme Regulation:
- ENZYME REGULATION: Activity of phosphorylase is controlled both by allosteric means (through the noncovalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.
- Cross Reference Drug Bank:
- DB00131
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
plasma membrane
AMP binding
ATP binding
bile acid binding
drug binding
glucose binding
glycogen phosphorylase activity
protein homodimerization activity
purine nucleobase binding
pyridoxal phosphate binding
vitamin binding
5-phosphoribose 1-diphosphate biosynthetic process
carbohydrate metabolic process
glucose homeostasis
glucose metabolic process
glycogen catabolic process
glycogen metabolic process
necroptotic process
small molecule metabolic process - Gene Ontology Biological Process:
- 5-phosphoribose 1-diphosphate biosynthetic process
carbohydrate metabolic process
glucose homeostasis
glucose metabolic process
glycogen catabolic process
glycogen metabolic process
necroptotic process
small molecule metabolic process - Gene Ontology Molecular Function:
- AMP binding
ATP binding
bile acid binding
drug binding
glucose binding
glycogen phosphorylase activity
protein homodimerization activity
purine nucleobase binding
pyridoxal phosphate binding
vitamin binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
plasma membrane - Keywords:
- 3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Carbohydrate metabolism
Complete proteome
Disease mutation
Glycogen metabolism
Glycogen storage disease
Glycosyltransferase
Nucleotide-binding
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase - Interacts With:
- P11216