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Names & Taxonomy

Uniprot ID:: P06733
Entry Name:: ENOA_HUMAN
Status:: reviewed
Protein Names:: Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)
Gene Names:: ENO1 ENO1L1 MBPB1 MPB1
Gene Names Primary:: ENO1
Organism:: Homo sapiens (Human)

Structure

Length:: 434
Sequence:: MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm

Function

Function:: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.; MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Pathway:: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Catalytic Activity:: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
Cofactor:: COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:: ACT_SITE 210 210 Proton donor.
Gene Ontology Go:: cytoplasm
cytosol
extracellular exosome
extracellular space
extrinsic component of plasma membrane
M band
membrane
myelin sheath
nucleus
phosphopyruvate hydratase complex
DNA binding
GTPase binding
magnesium ion binding
phosphopyruvate hydratase activity
poly(A) RNA binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
in utero embryonic development
negative regulation of cell growth
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of binding
response to virus
small molecule metabolic process
transcription, DNA-templated
Gene Ontology Biological Process:: canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
in utero embryonic development
negative regulation of cell growth
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
positive regulation of binding
response to virus
small molecule metabolic process
transcription, DNA-templated
Gene Ontology Molecular Function:: DNA binding
GTPase binding
magnesium ion binding
phosphopyruvate hydratase activity
poly(A) RNA binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
Gene Ontology Cellular Component:: cytoplasm
cytosol
extracellular exosome
extracellular space
extrinsic component of plasma membrane
M band
membrane
myelin sheath
nucleus
phosphopyruvate hydratase complex
Keywords:: 3D-structure
Acetylation
Alternative initiation
Cell membrane
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Glycolysis
Lyase
Magnesium
Membrane
Metal-binding
Nucleus
Phosphoprotein
Plasminogen activation
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Interacts With:: P22303; Q60823; P12004; Q8WZ42; P63104

Names & Taxonomy

Structure

Subcellular location

Function

Publication