Names & Taxonomy
- Uniprot ID:
- P06732
- Entry Name:
- KCRM_HUMAN
- Status:
- reviewed
- Protein Names:
- Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (M-CK) [Cleaved into: Creatine kinase M-type, N-terminally processed]
- Gene Names:
- CKM CKMM
- Gene Names Primary:
- CKM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 381
- Sequence:
- MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- Catalytic Activity:
- ATP + creatine = ADP + phosphocreatine.
- Cross Reference Drug Bank:
- DB00148
- Gene Ontology Go:
- cytosol
ATP binding
creatine kinase activity
cellular nitrogen compound metabolic process
creatine metabolic process
phosphocreatine biosynthetic process
polyamine metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
creatine metabolic process
phosphocreatine biosynthetic process
polyamine metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
creatine kinase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Complete proteome
Cytoplasm
Direct protein sequencing
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q96DX5