Names & Taxonomy
- Uniprot ID:
- P06730
- Entry Name:
- IF4E_HUMAN
- Status:
- reviewed
- Protein Names:
- Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
- Gene Names:
- EIF4E EIF4EL1 EIF4F
- Gene Names Primary:
- EIF4E
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 217
- Sequence:
- MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, P-body
Function
- Function:
- Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
- Gene Ontology Go:
- chromatoid body
cytoplasm
cytoplasmic mRNA processing body
cytoplasmic stress granule
cytosol
eukaryotic translation initiation factor 4F complex
extracellular exosome
mRNA cap binding complex
perinuclear region of cytoplasm
RISC complex
enzyme binding
eukaryotic initiation factor 4G binding
poly(A) RNA binding
repressing transcription factor binding
RNA cap binding
translation initiation factor activity
behavioral fear response
cellular protein metabolic process
cytokine-mediated signaling pathway
G1/S transition of mitotic cell cycle
gene expression
insulin receptor signaling pathway
lung development
mRNA export from nucleus
negative regulation of neuron differentiation
negative regulation of translation
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of mitotic cell cycle
regulation of translation
stem cell population maintenance
translation
translational initiation
viral process - Gene Ontology Biological Process:
- behavioral fear response
cellular protein metabolic process
cytokine-mediated signaling pathway
G1/S transition of mitotic cell cycle
gene expression
insulin receptor signaling pathway
lung development
mRNA export from nucleus
negative regulation of neuron differentiation
negative regulation of translation
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of mitotic cell cycle
regulation of translation
stem cell population maintenance
translation
translational initiation
viral process - Gene Ontology Molecular Function:
- enzyme binding
eukaryotic initiation factor 4G binding
poly(A) RNA binding
repressing transcription factor binding
RNA cap binding
translation initiation factor activity - Gene Ontology Cellular Component:
- chromatoid body
cytoplasm
cytoplasmic mRNA processing body
cytoplasmic stress granule
cytosol
eukaryotic translation initiation factor 4F complex
extracellular exosome
mRNA cap binding complex
perinuclear region of cytoplasm
RISC complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Autism
Autism spectrum disorder
Chromosomal rearrangement
Complete proteome
Cytoplasm
Direct protein sequencing
Host-virus interaction
Initiation factor
Phosphoprotein
Protein biosynthesis
RNA-binding
Reference proteome
Translation regulation - Interacts With:
- Q13541; Q13542; O60516; Q9NRA8; Q04637; Q04743; Q8TEQ6; Q63ZY3; P42704; P63165; P48775; P14373; Q5T124
Publication
- PubMed ID:
- 3469651 1736299 14702039 15815621 15489334 16341674 1993647 1672854 3112145 8505316 7590282 7782323 7665584 8521827 10856257 9878069 11408474 11154262 12897141 16699599 19413330 19556253 20430826 20616046 21269460 22578813 24207126 25533957 11879179 12975586 16271312 17036047 17631896 21661078