Names & Taxonomy
- Uniprot ID:
- P06729
- Entry Name:
- CD2_HUMAN
- Status:
- reviewed
- Protein Names:
- T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
- Gene Names:
- CD2 SRBC
- Gene Names Primary:
- CD2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 351
- Sequence:
- MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
- Cross Reference Drug Bank:
- DB00092
- Gene Ontology Go:
- anchored component of plasma membrane
cell surface
cell-cell junction
cytoplasmic side of plasma membrane
external side of plasma membrane
extracellular region
integral component of plasma membrane
plasma membrane
receptor activity
receptor binding
apoptotic process
blood coagulation
cell surface receptor signaling pathway
heterotypic cell-cell adhesion
leukocyte migration
membrane raft polarization
natural killer cell activation
positive regulation of interferon-gamma secretion
positive regulation of interleukin-8 secretion
positive regulation of myeloid dendritic cell activation
positive regulation of tumor necrosis factor production
regulation of T cell differentiation
single organismal cell-cell adhesion
T cell activation - Gene Ontology Biological Process:
- apoptotic process
blood coagulation
cell surface receptor signaling pathway
heterotypic cell-cell adhesion
leukocyte migration
membrane raft polarization
natural killer cell activation
positive regulation of interferon-gamma secretion
positive regulation of interleukin-8 secretion
positive regulation of myeloid dendritic cell activation
positive regulation of tumor necrosis factor production
regulation of T cell differentiation
single organismal cell-cell adhesion
T cell activation - Gene Ontology Molecular Function:
- receptor activity
receptor binding - Gene Ontology Cellular Component:
- anchored component of plasma membrane
cell-cell junction
cell surface
cytoplasmic side of plasma membrane
external side of plasma membrane
extracellular region
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q9Y5K6; O95400; Q96B97