Names & Taxonomy
- Uniprot ID:
- P06401
- Entry Name:
- PRGR_HUMAN
- Status:
- reviewed
- Protein Names:
- Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
- Gene Names:
- PGR NR3C3
- Gene Names Primary:
- PGR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 933
- Sequence:
- MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.; Isoform 4: Mitochondrion outer membrane
Function
- Function:
- The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.; Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.; Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
- Cross Reference Drug Bank:
- DB01431 DB01406 DB00304 DB01395 DB00378 DB00823 DB00294 DB00588 DB06789 DB00367 DB00603 DB00351 DB00834 DB06713 DB00717 DB00957 DB00396 DB00421 DB08867
- Gene Ontology Go:
- mitochondrial outer membrane
nucleoplasm
ATPase binding
DNA binding
enzyme binding
receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
cell-cell signaling
gene expression
negative regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cell-cell signaling
gene expression
negative regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- ATPase binding
DNA binding
enzyme binding
receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding - Gene Ontology Cellular Component:
- mitochondrial outer membrane
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Isopeptide bond
Lipid-binding
Lipoprotein
Membrane
Metal-binding
Mitochondrion
Mitochondrion outer membrane
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Steroid-binding
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- Q9H467; P40763