Names & Taxonomy

Uniprot ID:
P06401
Entry Name:
PRGR_HUMAN
Status:
reviewed
Protein Names:
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene Names:
PGR NR3C3
Gene Names Primary:
PGR
Organism:
Homo sapiens (Human)

Structure

Length:
933
Sequence:
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.; Isoform 4: Mitochondrion outer membrane

Function

Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.; Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.; Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Cross Reference Drug Bank:
DB01431 DB01406 DB00304 DB01395 DB00378 DB00823 DB00294 DB00588 DB06789 DB00367 DB00603 DB00351 DB00834 DB06713 DB00717 DB00957 DB00396 DB00421 DB08867
Gene Ontology Go:
mitochondrial outer membrane
nucleoplasm
ATPase binding
DNA binding
enzyme binding
receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
cell-cell signaling
gene expression
negative regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
signal transduction
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:
cell-cell signaling
gene expression
negative regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
signal transduction
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:
ATPase binding
DNA binding
enzyme binding
receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
Gene Ontology Cellular Component:
mitochondrial outer membrane
nucleoplasm
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Isopeptide bond
Lipid-binding
Lipoprotein
Membrane
Metal-binding
Mitochondrion
Mitochondrion outer membrane
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Steroid-binding
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger
Interacts With:
Q9H467; P40763

Publication

PubMed ID:
2328727 3551956 18375150 12644308 14702039 16554811 11110801 23518922 7476977 8702648 9171245 10628747 10655479 12039952 12917342 15572662 15798179 16478993 17020914 17347654 17717077 17173941 18202149 22031296 9620806 15937332