Names & Taxonomy
- Uniprot ID:
- P06400
- Entry Name:
- RB_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
- Gene Names:
- RB1
- Gene Names Primary:
- RB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 928
- Sequence:
- MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
- Cross Reference Drug Bank:
- DB00030
- Gene Ontology Go:
- chromatin
nucleoplasm
nucleus
PML body
Rb-E2F complex
spindle
SWI/SNF complex
androgen receptor binding
core promoter binding
DNA binding
identical protein binding
kinase binding
phosphoprotein binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
ubiquitin protein ligase binding
androgen receptor signaling pathway
cell cycle arrest
cell cycle checkpoint
cell division
cell morphogenesis involved in neuron differentiation
cellular response to xenobiotic stimulus
chromatin remodeling
digestive tract development
enucleate erythrocyte differentiation
G1/S transition of mitotic cell cycle
glial cell apoptotic process
hepatocyte apoptotic process
maintenance of mitotic sister chromatid cohesion
mitotic cell cycle
mitotic cell cycle checkpoint
myoblast differentiation
negative regulation of epithelial cell proliferation
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of protein kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of smoothened signaling pathway
negative regulation of transcription from RNA polymerase II promoter during mitosis
negative regulation of transcription involved in G1/S transition of mitotic cell cycle
negative regulation of transcription, DNA-templated
neuron apoptotic process
neuron maturation
neuron projection development
positive regulation of macrophage differentiation
positive regulation of mitotic metaphase/anaphase transition
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
protein localization to chromosome, centromeric region
Ras protein signal transduction
regulation of centromere complex assembly
regulation of cohesin localization to chromatin
regulation of lipid kinase activity
regulation of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
sister chromatid biorientation
skeletal muscle cell differentiation
striated muscle cell differentiation
transcription, DNA-templated
viral process - Gene Ontology Biological Process:
- androgen receptor signaling pathway
cell cycle arrest
cell cycle checkpoint
cell division
cell morphogenesis involved in neuron differentiation
cellular response to xenobiotic stimulus
chromatin remodeling
digestive tract development
enucleate erythrocyte differentiation
G1/S transition of mitotic cell cycle
glial cell apoptotic process
hepatocyte apoptotic process
maintenance of mitotic sister chromatid cohesion
mitotic cell cycle
mitotic cell cycle checkpoint
myoblast differentiation
negative regulation of epithelial cell proliferation
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of protein kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter during mitosis
negative regulation of transcription involved in G1/S transition of mitotic cell cycle
neuron apoptotic process
neuron maturation
neuron projection development
positive regulation of macrophage differentiation
positive regulation of mitotic metaphase/anaphase transition
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein localization to chromosome, centromeric region
Ras protein signal transduction
regulation of centromere complex assembly
regulation of cohesin localization to chromatin
regulation of lipid kinase activity
regulation of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
sister chromatid biorientation
skeletal muscle cell differentiation
striated muscle cell differentiation
transcription, DNA-templated
viral process - Gene Ontology Molecular Function:
- androgen receptor binding
core promoter binding
DNA binding
identical protein binding
kinase binding
phosphoprotein binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- chromatin
nucleoplasm
nucleus
PML body
Rb-E2F complex
spindle
SWI/SNF complex - Keywords:
- 3D-structure
Acetylation
Cell cycle
Chromatin regulator
Complete proteome
DNA-binding
Direct protein sequencing
Disease mutation
Host-virus interaction
Methylation
Nucleus
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Repressor
Transcription
Transcription regulation - Interacts With:
- Itself; P03070; P03255; P03255-1; P03255-2; P24941; P30285; Q155P7; O14757; O96017; Q13574-2; Q13627; Q9Y463; Q01094; Q14209; O00716; A0MPS7; P03129; P04020; P06464; P06465; P06788; O43524; P42685; P62993; O60381; Q13547; P52927; Q9R002; Q14653; Q16539; Q00987; O15151; Q14686; P07197; Q8VSP9; Q9UQ80; P62136; P55345; Q00577; P04049; O75150; Q8WTS6; Q923E4; Q3TKT4; Q96PU4; Q93009
Publication
- PubMed ID:
- 3657987 3823889 3480530 2701949 1352398 7902321 14702039 15057823 15489334 2717184 1316611 7881418 8114739 2839300 3413073 1756735 8414517 7525595 7935440 8892909 10446990 10499802 10409732 10779342 9858607 10869426 11223246 10888886 11484059 11571652 12450794 12475961 12466551 12037672 12682072 15084261 15538385 15107404 15542589 15809340 15927959 15803180 15949438 16337594 16214886 16645588 17380128 18220336 18669648 19413330 19690332 19608861 20870719 20940255 20068231 21269460 21952639 21406692 22787429 24275569 9145110 9495340 12695505 16360038 17974914 17996702 2594029 1352883 8346255 7704558 7927327 8605116 7795591 8776589 9311732 9140452 10671068 9973307 11524739 23033978