Names & Taxonomy
- Uniprot ID:
- P06396
- Entry Name:
- GELS_HUMAN
- Status:
- reviewed
- Protein Names:
- Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)
- Gene Names:
- GSN
- Gene Names Primary:
- GSN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 782
- Sequence:
- MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEARPNSMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 2: Cytoplasm, cytoskeleton.; Isoform 1: Secreted.
Function
- Function:
- Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
- Gene Ontology Go:
- actin cap
actin cytoskeleton
blood microparticle
cortical actin cytoskeleton
cytoplasm
cytosol
extracellular exosome
extracellular region
extracellular space
focal adhesion
lamellipodium
myelin sheath
perinuclear region of cytoplasm
plasma membrane
podosome
ruffle
sarcoplasm
actin binding
calcium ion binding
myosin II binding
protein domain specific binding
actin filament capping
actin filament polymerization
actin filament reorganization
actin filament severing
actin nucleation
aging
amyloid fibril formation
apoptotic process
barbed-end actin filament capping
cellular component disassembly involved in execution phase of apoptosis
cellular protein metabolic process
cellular response to cadmium ion
cilium morphogenesis
hepatocyte apoptotic process
negative regulation of viral entry into host cell
oligodendrocyte development
phagocytosis, engulfment
phosphatidylinositol-mediated signaling
positive regulation of actin nucleation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of gene expression
positive regulation of keratinocyte apoptotic process
positive regulation of protein processing in phagocytic vesicle
programmed cell death
protein destabilization
regulation of establishment of T cell polarity
regulation of plasma membrane raft polarization
regulation of podosome assembly
regulation of receptor clustering
regulation of wound healing, spreading of epidermal cells
renal protein absorption
response to ethanol
response to folic acid
sequestering of actin monomers
striated muscle atrophy
tissue regeneration - Gene Ontology Biological Process:
- actin filament capping
actin filament polymerization
actin filament reorganization
actin filament severing
actin nucleation
aging
amyloid fibril formation
apoptotic process
barbed-end actin filament capping
cellular component disassembly involved in execution phase of apoptosis
cellular protein metabolic process
cellular response to cadmium ion
cilium morphogenesis
hepatocyte apoptotic process
negative regulation of viral entry into host cell
oligodendrocyte development
phagocytosis, engulfment
phosphatidylinositol-mediated signaling
positive regulation of actin nucleation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of gene expression
positive regulation of keratinocyte apoptotic process
positive regulation of protein processing in phagocytic vesicle
programmed cell death
protein destabilization
regulation of establishment of T cell polarity
regulation of plasma membrane raft polarization
regulation of podosome assembly
regulation of receptor clustering
regulation of wound healing, spreading of epidermal cells
renal protein absorption
response to ethanol
response to folic acid
sequestering of actin monomers
striated muscle atrophy
tissue regeneration - Gene Ontology Molecular Function:
- actin binding
calcium ion binding
myosin II binding
protein domain specific binding - Gene Ontology Cellular Component:
- actin cap
actin cytoskeleton
blood microparticle
cortical actin cytoskeleton
cytoplasm
cytosol
extracellular exosome
extracellular region
extracellular space
focal adhesion
lamellipodium
myelin sheath
perinuclear region of cytoplasm
plasma membrane
podosome
ruffle
sarcoplasm - Keywords:
- 3D-structure
Acetylation
Actin capping
Actin-binding
Alternative initiation
Alternative splicing
Amyloid
Amyloidosis
Calcium
Cilium biogenesis/degradation
Complete proteome
Corneal dystrophy
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Disulfide bond
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- P49407; P32121