Names & Taxonomy
- Uniprot ID:
- P06276
- Entry Name:
- CHLE_HUMAN
- Status:
- reviewed
- Protein Names:
- Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)
- Gene Names:
- BCHE CHE1
- Gene Names Primary:
- BCHE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 602
- Sequence:
- MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
- Catalytic Activity:
- An acylcholine + H(2)O = choline + a carboxylate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=18.0 uM for butyrylthiocholine (at 25 degrees Celsius)
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by mercury. Inhibited by Tabun. Tabun forms a covalent adduct with Ser-226 that becomes irreversible upon aging.
- Active Site:
- ACT_SITE 226 226 Acyl-ester intermediate.
- Cross Reference Drug Bank:
- DB08897 DB01122 DB01408 DB06774 DB01161 DB00856 DB00477 DB00122 DB00527 DB00515 DB04920 DB00979 DB01245 DB00944 DB00711 DB00449 DB01135 DB01395 DB01057 DB01010 DB01364 DB00392 DB00674 DB06756 DB00941 DB00762 DB00677 DB00772 DB00358 DB08893 DB01226 DB01400 DB00585 DB00892 DB01337 DB00082 DB00183 DB00790 DB01338 DB00733 DB01035 DB00721 DB00545 DB00178 DB00989 DB00202 DB00391 DB00871 DB00620 DB00508 DB01116
- Gene Ontology Go:
- blood microparticle
endoplasmic reticulum lumen
extracellular region
membrane
nuclear envelope lumen
acetylcholinesterase activity
beta-amyloid binding
catalytic activity
choline binding
cholinesterase activity
enzyme binding
identical protein binding
cellular protein metabolic process
choline metabolic process
cocaine metabolic process
learning
negative regulation of cell proliferation
negative regulation of synaptic transmission
neuroblast differentiation
response to alkaloid
response to drug
response to folic acid
response to glucocorticoid - Gene Ontology Biological Process:
- cellular protein metabolic process
choline metabolic process
cocaine metabolic process
learning
negative regulation of cell proliferation
negative regulation of synaptic transmission
neuroblast differentiation
response to alkaloid
response to drug
response to folic acid
response to glucocorticoid - Gene Ontology Molecular Function:
- acetylcholinesterase activity
beta-amyloid binding
catalytic activity
choline binding
cholinesterase activity
enzyme binding
identical protein binding - Gene Ontology Cellular Component:
- blood microparticle
endoplasmic reticulum lumen
extracellular region
membrane
nuclear envelope lumen - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Serine esterase
Sialic acid
Signal - Interacts With:
- Itself
Publication
- PubMed ID:
- 3035536 3477799 2322535 14702039 15489334 3542989 20946535 3115973 14760718 16335952 18203274 19542320 19159218 19139490 19452557 22444575 24275569 25054547 12869558 15667209 17768338 17355286 18975951 19368529 23679855 2915989 1349196 1415224 1611188 1306123 7634491 8680411 8554068 9543549 9388484 9191541 9110359 9694584 10404729 11928765 12881446 15563885 15781196 16788378 17700357 18075469 18300943 25264279