Names & Taxonomy
- Uniprot ID:
- P05787
- Entry Name:
- K2C8_HUMAN
- Status:
- reviewed
- Protein Names:
- Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
- Gene Names:
- KRT8 CYK8
- Gene Names Primary:
- KRT8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 483
- Sequence:
- MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
- Cross Reference Drug Bank:
- DB00031
- Gene Ontology Go:
- cell-cell junction
costamere
cytoplasm
dystrophin-associated glycoprotein complex
extracellular exosome
intermediate filament
keratin filament
nuclear matrix
nucleoplasm
nucleus
sarcolemma
Z disc
scaffold protein binding
structural molecule activity
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
response to hydrostatic pressure
response to other organism
sarcomere organization
tumor necrosis factor-mediated signaling pathway
viral process - Gene Ontology Biological Process:
- cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
response to hydrostatic pressure
response to other organism
sarcomere organization
tumor necrosis factor-mediated signaling pathway
viral process - Gene Ontology Molecular Function:
- scaffold protein binding
structural molecule activity - Gene Ontology Cellular Component:
- cell-cell junction
costamere
cytoplasm
dystrophin-associated glycoprotein complex
extracellular exosome
intermediate filament
keratin filament
nuclear matrix
nucleoplasm
nucleus
sarcolemma
Z disc - Keywords:
- Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycoprotein
Host-virus interaction
Intermediate filament
Isopeptide bond
Keratin
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation - Interacts With:
- P13569; P62993; Q9Y6K9; A1A4E9; P19012; P05783; Q15323; O76015; Q6A162; Q13835-2; P14079; Q9UBB9
Publication
- PubMed ID:
- 1691124 1692965 1705144 9054461 14702039 16541075 15489334 2471065 2434381 9150948 1371281 1374067 10973561 10809736 11781324 11788583 15731013 16000376 15846844 17081983 16608857 16964243 18691976 18669648 19188445 19369195 19608861 20729549 20068231 21269460 21908771 21149639 21406692 22967762 24275569 25218447 12724528