Names & Taxonomy
- Uniprot ID:
- P05187
- Entry Name:
- PPB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)
- Gene Names:
- ALPP PLAP
- Gene Names Primary:
- ALPP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 535
- Sequence:
- MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor.
Function
- Catalytic Activity:
- A phosphate monoester + H(2)O = an alcohol + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion.;; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions.;
- Active Site:
- ACT_SITE 114 114 Phosphoserine intermediate.
- Gene Ontology Go:
- anchored component of membrane
cell surface
integral component of membrane
plasma membrane
alkaline phosphatase activity
magnesium ion binding
zinc ion binding
dephosphorylation - Gene Ontology Biological Process:
- dephosphorylation
- Gene Ontology Molecular Function:
- alkaline phosphatase activity
magnesium ion binding
zinc ion binding - Gene Ontology Cellular Component:
- anchored component of membrane
cell surface
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Magnesium
Membrane
Metal-binding
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zinc - Interacts With:
- Q9BQ66; P26371