Names & Taxonomy
- Uniprot ID:
- P05141
- Entry Name:
- ADT2_HUMAN
- Status:
- reviewed
- Protein Names:
- ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]
- Gene Names:
- SLC25A5 ANT2
- Gene Names Primary:
- SLC25A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 298
- Sequence:
- MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Multi-pass membrane protein.
Function
- Function:
- Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
- Cross Reference Drug Bank:
- DB00720
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
membrane
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrion
MMXD complex
myelin sheath
nucleus
adenine transmembrane transporter activity
poly(A) RNA binding
structural constituent of ribosome
ubiquitin protein ligase binding
adenine transport
chromosome segregation
energy reserve metabolic process
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of cell proliferation
regulation of insulin secretion
small molecule metabolic process
translation
transport
viral process - Gene Ontology Biological Process:
- adenine transport
chromosome segregation
energy reserve metabolic process
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of cell proliferation
regulation of insulin secretion
small molecule metabolic process
translation
transport
viral process - Gene Ontology Molecular Function:
- adenine transmembrane transporter activity
poly(A) RNA binding
structural constituent of ribosome
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane
membrane
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrion
MMXD complex
myelin sheath
nucleus - Keywords:
- Acetylation
Chromosome partition
Complete proteome
Direct protein sequencing
Host-virus interaction
Membrane
Methylation
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q5S007; Q9Y6E7; Q8N357