Names & Taxonomy
- Uniprot ID:
- P05121
- Entry Name:
- PAI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
- Gene Names:
- SERPINE1 PAI1 PLANH1
- Gene Names Primary:
- SERPINE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 402
- Sequence:
- MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
- Cross Reference Drug Bank:
- DB00009 DB00029 DB00055 DB00015 DB00031 DB00013
- Gene Ontology Go:
- extracellular exosome
extracellular matrix
extracellular region
extracellular space
plasma membrane
platelet alpha granule lumen
protease binding
receptor binding
serine-type endopeptidase inhibitor activity
angiogenesis
blood coagulation
cellular response to lipopolysaccharide
chronological cell aging
circadian rhythm
defense response to Gram-negative bacterium
extracellular matrix organization
fibrinolysis
gene expression
negative regulation of blood coagulation
negative regulation of cell adhesion mediated by integrin
negative regulation of cell migration
negative regulation of endopeptidase activity
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of fibrinolysis
negative regulation of plasminogen activation
negative regulation of smooth muscle cell migration
negative regulation of smooth muscle cell-matrix adhesion
negative regulation of vascular wound healing
negative regulation of wound healing
platelet activation
platelet degranulation
positive regulation of angiogenesis
positive regulation of blood coagulation
positive regulation of inflammatory response
positive regulation of interleukin-8 production
positive regulation of leukotriene production involved in inflammatory response
positive regulation of monocyte chemotaxis
positive regulation of receptor-mediated endocytosis
positive regulation of transcription from RNA polymerase II promoter
regulation of receptor activity
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway - Gene Ontology Biological Process:
- angiogenesis
blood coagulation
cellular response to lipopolysaccharide
chronological cell aging
circadian rhythm
defense response to Gram-negative bacterium
extracellular matrix organization
fibrinolysis
gene expression
negative regulation of blood coagulation
negative regulation of cell adhesion mediated by integrin
negative regulation of cell migration
negative regulation of endopeptidase activity
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of fibrinolysis
negative regulation of plasminogen activation
negative regulation of smooth muscle cell-matrix adhesion
negative regulation of smooth muscle cell migration
negative regulation of vascular wound healing
negative regulation of wound healing
platelet activation
platelet degranulation
positive regulation of angiogenesis
positive regulation of blood coagulation
positive regulation of inflammatory response
positive regulation of interleukin-8 production
positive regulation of leukotriene production involved in inflammatory response
positive regulation of monocyte chemotaxis
positive regulation of receptor-mediated endocytosis
positive regulation of transcription from RNA polymerase II promoter
regulation of receptor activity
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway - Gene Ontology Molecular Function:
- protease binding
receptor binding
serine-type endopeptidase inhibitor activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular matrix
extracellular region
extracellular space
plasma membrane
platelet alpha granule lumen - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Glycoprotein
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal - Interacts With:
- P02763; O43765; Q96EQ0; Q9UMX0; Q9UMX0-2