Names & Taxonomy

Uniprot ID:
P05120
Entry Name:
PAI2_HUMAN
Status:
reviewed
Protein Names:
Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor)
Gene Names:
SERPINB2 PAI2 PLANH2
Gene Names Primary:
SERPINB2
Organism:
Homo sapiens (Human)

Structure

Length:
415
Sequence:
MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Secreted, extracellular space.

Function

Function:
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
Cross Reference Drug Bank:
DB00031 DB00013
Gene Ontology Go:
cytoplasm
extracellular region
extracellular space
plasma membrane
serine-type endopeptidase inhibitor activity
blood coagulation
fibrinolysis
negative regulation of apoptotic process
negative regulation of endopeptidase activity
Gene Ontology Biological Process:
blood coagulation
fibrinolysis
negative regulation of apoptotic process
negative regulation of endopeptidase activity
Gene Ontology Molecular Function:
serine-type endopeptidase inhibitor activity
Gene Ontology Cellular Component:
cytoplasm
extracellular region
extracellular space
plasma membrane
Keywords:
3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Plasminogen activation
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal

Publication

PubMed ID:
3029122 3325828 3496414 3257578 2494165 2303256 15489334 1286667 14732874 21269460 10368272 10391209