Names & Taxonomy

Uniprot ID:
P05093
Entry Name:
CP17A_HUMAN
Status:
reviewed
Protein Names:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 4.1.2.30) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
Gene Names:
CYP17A1 CYP17 S17AH
Gene Names Primary:
CYP17A1
Organism:
Homo sapiens (Human)

Structure

Length:
508
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Pathway:
Lipid metabolism; steroid biosynthesis.
Catalytic Activity:
A C(21)-steroid + + O(2) = a 17-alpha-hydroxy-C(21)-steroid + + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Enzyme Regulation:
ENZYME REGULATION: Regulated predominantly by intracellular cAMP levels.
Cross Reference Drug Bank:
DB05812 DB01424 DB01234 DB01233 DB00396
Gene Ontology Go:
axon
endoplasmic reticulum
endoplasmic reticulum membrane
mitochondrion
neuronal cell body
17-alpha-hydroxyprogesterone aldolase activity
heme binding
iron ion binding
oxygen binding
steroid 17-alpha-monooxygenase activity
adrenal gland development
androgen biosynthetic process
biphenyl metabolic process
cellular response to antibiotic
cellular response to gonadotropin stimulus
cellular response to lipopolysaccharide
dibenzo-p-dioxin metabolic process
glucocorticoid biosynthetic process
hippocampus development
hormone biosynthetic process
Leydig cell differentiation
ovulation
phenol-containing compound metabolic process
phthalate metabolic process
positive regulation of steroid hormone biosynthetic process
progesterone metabolic process
response to acetate
response to cAMP
response to cytokine
response to drug
response to fungicide
response to herbicide
response to insecticide
response to ionizing radiation
response to methylmercury
response to nutrient levels
response to retinoic acid
response to steroid hormone
sex differentiation
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
adrenal gland development
androgen biosynthetic process
biphenyl metabolic process
cellular response to antibiotic
cellular response to gonadotropin stimulus
cellular response to lipopolysaccharide
dibenzo-p-dioxin metabolic process
glucocorticoid biosynthetic process
hippocampus development
hormone biosynthetic process
Leydig cell differentiation
ovulation
phenol-containing compound metabolic process
phthalate metabolic process
positive regulation of steroid hormone biosynthetic process
progesterone metabolic process
response to acetate
response to cAMP
response to cytokine
response to drug
response to fungicide
response to herbicide
response to insecticide
response to ionizing radiation
response to methylmercury
response to nutrient levels
response to retinoic acid
response to steroid hormone
sex differentiation
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
17-alpha-hydroxyprogesterone aldolase activity
heme binding
iron ion binding
oxygen binding
steroid 17-alpha-monooxygenase activity
Gene Ontology Cellular Component:
axon
endoplasmic reticulum
endoplasmic reticulum membrane
mitochondrion
neuronal cell body
Keywords:
3D-structure
Complete proteome
Congenital adrenal hyperplasia
Disease mutation
Heme
Iron
Lyase
Membrane
Metal-binding
Monooxygenase
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Steroidogenesis

Publication

PubMed ID:
3025870 3500022 3274893 1964490 2843762 15164054 15489334 10406467 22266943 2808364 1714904 1515452 1740503 8396144 8245018 8345056 8027220 8550762 10720067 11549685 11836339 12466376 14671162 19793597 24498484 24140098 25650406