Names & Taxonomy

Uniprot ID:
P05062
Entry Name:
ALDOB_HUMAN
Status:
reviewed
Protein Names:
Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase)
Gene Names:
ALDOB ALDB
Gene Names Primary:
ALDOB
Organism:
Homo sapiens (Human)

Structure

Length:
364
Sequence:
MAHRFPALTQEQKKELSEIAQSIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFREILFSVDSSINQSIGGVILFHETLYQKDSQGKLFRNILKEKGIVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPSSLAIQENANALARYASICQQNGLVPIVEPEVIPDGDHDLEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMSEEDATLNLNAINLCPLPKPWKLSFSYGRALQASALAAWGGKAANKEATQEAFMKRAMANCQAAKGQYVHTGSSGAASTQSLFTACYTY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite

Function

Pathway:
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Catalytic Activity:
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.6 uM for fructose 1,6-bisphosphate
Active Site:
ACT_SITE 188 188 Proton acceptor.
Gene Ontology Go:
centriolar satellite
cytosol
extracellular exosome
lysosome
microtubule organizing center
nucleus
perinuclear region of cytoplasm
plasma membrane
rough endoplasmic reticulum membrane
smooth endoplasmic reticulum membrane
ATPase binding
cytoskeletal protein binding
fructose binding
fructose-1-phosphate aldolase activity
fructose-bisphosphate aldolase activity
identical protein binding
phosphatidylcholine binding
canonical glycolysis
carbohydrate metabolic process
cellular response to extracellular stimulus
cellular response to insulin stimulus
fructose 1,6-bisphosphate metabolic process
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
liver development
NADH oxidation
positive regulation of ATPase activity
response to amino acid
response to cAMP
response to copper ion
response to drug
response to fructose
response to glucocorticoid
response to interleukin-6
response to starvation
response to zinc ion
small molecule metabolic process
vacuolar proton-transporting V-type ATPase complex assembly
Gene Ontology Biological Process:
canonical glycolysis
carbohydrate metabolic process
cellular response to extracellular stimulus
cellular response to insulin stimulus
fructose 1,6-bisphosphate metabolic process
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
liver development
NADH oxidation
positive regulation of ATPase activity
response to amino acid
response to cAMP
response to copper ion
response to drug
response to fructose
response to glucocorticoid
response to interleukin-6
response to starvation
response to zinc ion
small molecule metabolic process
vacuolar proton-transporting V-type ATPase complex assembly
Gene Ontology Molecular Function:
ATPase binding
cytoskeletal protein binding
fructose-1-phosphate aldolase activity
fructose binding
fructose-bisphosphate aldolase activity
identical protein binding
phosphatidylcholine binding
Gene Ontology Cellular Component:
centriolar satellite
cytosol
extracellular exosome
lysosome
microtubule organizing center
nucleus
perinuclear region of cytoplasm
plasma membrane
rough endoplasmic reticulum membrane
smooth endoplasmic reticulum membrane
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Glycolysis
Lyase
Phosphoprotein
Polymorphism
Reference proteome
Schiff base
Interacts With:
Q8NFJ9; Q9BXC9; Q96RK4; Q8IWZ6

Publication

PubMed ID:
6548561 2410860 6585824 2830249 3016456 15164053 2649152 6689266 18000879 24275569 11679716 8535439 3383242 1967768 8299883 7717389 8162030 2336380 10024431 10970798 12205126 15532022 15880727 20848650