Names & Taxonomy
- Uniprot ID:
- P05062
- Entry Name:
- ALDOB_HUMAN
- Status:
- reviewed
- Protein Names:
- Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase)
- Gene Names:
- ALDOB ALDB
- Gene Names Primary:
- ALDOB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 364
- Sequence:
- MAHRFPALTQEQKKELSEIAQSIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFREILFSVDSSINQSIGGVILFHETLYQKDSQGKLFRNILKEKGIVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPSSLAIQENANALARYASICQQNGLVPIVEPEVIPDGDHDLEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMSEEDATLNLNAINLCPLPKPWKLSFSYGRALQASALAAWGGKAANKEATQEAFMKRAMANCQAAKGQYVHTGSSGAASTQSLFTACYTY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Function
- Pathway:
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
- Catalytic Activity:
- D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.6 uM for fructose 1,6-bisphosphate
- Active Site:
- ACT_SITE 188 188 Proton acceptor.
- Gene Ontology Go:
- centriolar satellite
cytosol
extracellular exosome
lysosome
microtubule organizing center
nucleus
perinuclear region of cytoplasm
plasma membrane
rough endoplasmic reticulum membrane
smooth endoplasmic reticulum membrane
ATPase binding
cytoskeletal protein binding
fructose binding
fructose-1-phosphate aldolase activity
fructose-bisphosphate aldolase activity
identical protein binding
phosphatidylcholine binding
canonical glycolysis
carbohydrate metabolic process
cellular response to extracellular stimulus
cellular response to insulin stimulus
fructose 1,6-bisphosphate metabolic process
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
liver development
NADH oxidation
positive regulation of ATPase activity
response to amino acid
response to cAMP
response to copper ion
response to drug
response to fructose
response to glucocorticoid
response to interleukin-6
response to starvation
response to zinc ion
small molecule metabolic process
vacuolar proton-transporting V-type ATPase complex assembly - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
cellular response to extracellular stimulus
cellular response to insulin stimulus
fructose 1,6-bisphosphate metabolic process
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
liver development
NADH oxidation
positive regulation of ATPase activity
response to amino acid
response to cAMP
response to copper ion
response to drug
response to fructose
response to glucocorticoid
response to interleukin-6
response to starvation
response to zinc ion
small molecule metabolic process
vacuolar proton-transporting V-type ATPase complex assembly - Gene Ontology Molecular Function:
- ATPase binding
cytoskeletal protein binding
fructose-1-phosphate aldolase activity
fructose binding
fructose-bisphosphate aldolase activity
identical protein binding
phosphatidylcholine binding - Gene Ontology Cellular Component:
- centriolar satellite
cytosol
extracellular exosome
lysosome
microtubule organizing center
nucleus
perinuclear region of cytoplasm
plasma membrane
rough endoplasmic reticulum membrane
smooth endoplasmic reticulum membrane - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Glycolysis
Lyase
Phosphoprotein
Polymorphism
Reference proteome
Schiff base - Interacts With:
- Q8NFJ9; Q9BXC9; Q96RK4; Q8IWZ6