Names & Taxonomy
- Uniprot ID:
- P04839
- Entry Name:
- CY24B_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (NADPH oxidase 2) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome)
- Gene Names:
- CYBB NOX2
- Gene Names Primary:
- CYBB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 570
- Sequence:
- MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB00514
- Gene Ontology Go:
- integral component of plasma membrane
mitochondrion
NADPH oxidase complex
phagocytic vesicle membrane
plasma membrane
flavin adenine dinucleotide binding
heme binding
metal ion binding
protein heterodimerization activity
superoxide-generating NADPH oxidase activity
voltage-gated ion channel activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
hydrogen peroxide biosynthetic process
inflammatory response
innate immune response
oxidation-reduction process
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
hydrogen peroxide biosynthetic process
inflammatory response
innate immune response
oxidation-reduction process
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
heme binding
metal ion binding
protein heterodimerization activity
superoxide-generating NADPH oxidase activity
voltage-gated ion channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
mitochondrion
NADPH oxidase complex
phagocytic vesicle membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Chronic granulomatous disease
Complete proteome
Direct protein sequencing
Disease mutation
Electron transport
FAD
Flavoprotein
Glycoprotein
Heme
Ion channel
Ion transport
Iron
Membrane
Metal-binding
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel