Names & Taxonomy

Uniprot ID:
P04818
Entry Name:
TYSY_HUMAN
Status:
reviewed
Protein Names:
Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
Gene Names:
TYMS TS OK/SW-cl.29
Gene Names Orf:
OK/SW-cl.29
Gene Names Primary:
TYMS
Organism:
Homo sapiens (Human)

Structure

Length:
313
Sequence:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Pathway:
Pyrimidine metabolism; dTTP biosynthesis.
Catalytic Activity:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Active Site:
ACT_SITE 195 195
Cross Reference Drug Bank:
DB01101 DB00322 DB00544 DB00441 DB00650 DB00563 DB00642 DB06813 DB00293 DB00432 DB00440
Gene Ontology Go:
cytoplasm
cytosol
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
nucleolus
nucleoplasm
nucleus
cofactor binding
drug binding
folic acid binding
mRNA binding
nucleotide binding
thymidylate synthase activity
aging
cartilage development
cell growth
cell proliferation
circadian rhythm
deoxyribonucleoside monophosphate biosynthetic process
developmental growth
DNA biosynthetic process
dTMP biosynthetic process
dTTP biosynthetic process
dUMP metabolic process
G1/S transition of mitotic cell cycle
immortalization of host cell by virus
intestinal epithelial cell maturation
mitotic cell cycle
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
organ regeneration
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
regulation of transcription involved in G1/S transition of mitotic cell cycle
response to cytokine
response to drug
response to ethanol
response to folic acid
response to glucocorticoid
response to organophosphorus
response to progesterone
response to toxic substance
response to vitamin A
small molecule metabolic process
tetrahydrofolate interconversion
uracil metabolic process
Gene Ontology Biological Process:
aging
cartilage development
cell growth
cell proliferation
circadian rhythm
deoxyribonucleoside monophosphate biosynthetic process
developmental growth
DNA biosynthetic process
dTMP biosynthetic process
dTTP biosynthetic process
dUMP metabolic process
G1/S transition of mitotic cell cycle
immortalization of host cell by virus
intestinal epithelial cell maturation
mitotic cell cycle
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
organ regeneration
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
regulation of transcription involved in G1/S transition of mitotic cell cycle
response to cytokine
response to drug
response to ethanol
response to folic acid
response to glucocorticoid
response to organophosphorus
response to progesterone
response to toxic substance
response to vitamin A
small molecule metabolic process
tetrahydrofolate interconversion
uracil metabolic process
Gene Ontology Molecular Function:
cofactor binding
drug binding
folic acid binding
mRNA binding
nucleotide binding
thymidylate synthase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
nucleolus
nucleoplasm
nucleus
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Membrane
Methyltransferase
Mitochondrion
Mitochondrion inner membrane
Nucleotide biosynthesis
Nucleus
Phosphoprotein
Reference proteome
Transferase

Publication

PubMed ID:
2987839 2243092 12706868 16177791 15489334 2532645 3839505 2656695 19690332 21269460 21876188 22814378 8845352 11329255 11278511