Names & Taxonomy

Uniprot ID:
P04731
Entry Name:
MT1A_HUMAN
Status:
reviewed
Protein Names:
Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)
Gene Names:
MT1A MT1S
Gene Names Primary:
MT1A
Organism:
Homo sapiens (Human)

Structure

Length:
61
Sequence:
MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA
Proteomes:
UP000005640

Function

Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Cross Reference Drug Bank:
DB00958 DB00515 DB00526
Gene Ontology Go:
cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm
zinc ion binding
cellular response to cadmium ion
cellular response to zinc ion
negative regulation of growth
response to metal ion
small molecule metabolic process
Gene Ontology Biological Process:
cellular response to cadmium ion
cellular response to zinc ion
negative regulation of growth
response to metal ion
small molecule metabolic process
Gene Ontology Molecular Function:
zinc ion binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm
Keywords:
Acetylation
Cadmium
Complete proteome
Copper
Metal-binding
Metal-thiolate cluster
Phosphoprotein
Polymorphism
Reference proteome
Zinc
Interacts With:
Q13585; P04637

Publication

PubMed ID:
6327055 15616553 15489334