Names & Taxonomy
- Uniprot ID:
- P04731
- Entry Name:
- MT1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)
- Gene Names:
- MT1A MT1S
- Gene Names Primary:
- MT1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 61
- Sequence:
- MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA
- Proteomes:
- UP000005640
Function
- Function:
- Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
- Cross Reference Drug Bank:
- DB00958 DB00515 DB00526
- Gene Ontology Go:
- cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm
zinc ion binding
cellular response to cadmium ion
cellular response to zinc ion
negative regulation of growth
response to metal ion
small molecule metabolic process - Gene Ontology Biological Process:
- cellular response to cadmium ion
cellular response to zinc ion
negative regulation of growth
response to metal ion
small molecule metabolic process - Gene Ontology Molecular Function:
- zinc ion binding
- Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleus
perinuclear region of cytoplasm - Keywords:
- Acetylation
Cadmium
Complete proteome
Copper
Metal-binding
Metal-thiolate cluster
Phosphoprotein
Polymorphism
Reference proteome
Zinc - Interacts With:
- Q13585; P04637