Names & Taxonomy

Uniprot ID:
P04424
Entry Name:
ARLY_HUMAN
Status:
reviewed
Protein Names:
Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase)
Gene Names:
ASL
Gene Names Primary:
ASL
Organism:
Homo sapiens (Human)

Structure

Length:
464
Sequence:
MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA
Proteomes:
UP000005640

Function

Pathway:
Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.; Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1.
Catalytic Activity:
2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.
Enzyme Regulation:
ENZYME REGULATION: Enzyme activity is regulated by acetylation.
Cross Reference Drug Bank:
DB00125
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
argininosuccinate lyase activity
arginine biosynthetic process
arginine biosynthetic process via ornithine
arginine catabolic process
cellular nitrogen compound metabolic process
internal protein amino acid acetylation
polyamine metabolic process
protein tetramerization
small molecule metabolic process
urea cycle
Gene Ontology Biological Process:
arginine biosynthetic process
arginine biosynthetic process via ornithine
arginine catabolic process
cellular nitrogen compound metabolic process
internal protein amino acid acetylation
polyamine metabolic process
protein tetramerization
small molecule metabolic process
urea cycle
Gene Ontology Molecular Function:
argininosuccinate lyase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
Keywords:
3D-structure
Acetylation
Alternative splicing
Amino-acid biosynthesis
Arginine biosynthesis
Complete proteome
Disease mutation
Lyase
Polymorphism
Reference proteome
Urea cycle
Interacts With:
Q96HA8

Publication

PubMed ID:
3391281 3463959 2644168 12853948 15489334 3368457 20167786 21269460 24275569 9256435 11747432 1705937 2263616 12408190 16959974 17326097 19703900 24166829