Names & Taxonomy
- Uniprot ID:
- P04424
- Entry Name:
- ARLY_HUMAN
- Status:
- reviewed
- Protein Names:
- Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase)
- Gene Names:
- ASL
- Gene Names Primary:
- ASL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 464
- Sequence:
- MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA
- Proteomes:
- UP000005640
Function
- Pathway:
- Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.; Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1.
- Catalytic Activity:
- 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.
- Enzyme Regulation:
- ENZYME REGULATION: Enzyme activity is regulated by acetylation.
- Cross Reference Drug Bank:
- DB00125
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
argininosuccinate lyase activity
arginine biosynthetic process
arginine biosynthetic process via ornithine
arginine catabolic process
cellular nitrogen compound metabolic process
internal protein amino acid acetylation
polyamine metabolic process
protein tetramerization
small molecule metabolic process
urea cycle - Gene Ontology Biological Process:
- arginine biosynthetic process
arginine biosynthetic process via ornithine
arginine catabolic process
cellular nitrogen compound metabolic process
internal protein amino acid acetylation
polyamine metabolic process
protein tetramerization
small molecule metabolic process
urea cycle - Gene Ontology Molecular Function:
- argininosuccinate lyase activity
- Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Amino-acid biosynthesis
Arginine biosynthesis
Complete proteome
Disease mutation
Lyase
Polymorphism
Reference proteome
Urea cycle - Interacts With:
- Q96HA8