Names & Taxonomy
- Uniprot ID:
- P04278
- Entry Name:
- SHBG_HUMAN
- Status:
- reviewed
- Protein Names:
- Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin)
- Gene Names:
- SHBG
- Gene Names Primary:
- SHBG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 402
- Sequence:
- MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
- Cross Reference Drug Bank:
- DB01406 DB00858 DB00783 DB04574 DB01185 DB00741 DB06710 DB00648 DB00717 DB06412 DB00421 DB00624 DB05275
- Gene Ontology Go:
- extracellular exosome
extracellular region
androgen binding - Gene Ontology Molecular Function:
- androgen binding
- Gene Ontology Cellular Component:
- extracellular exosome
extracellular region - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Lipid-binding
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Steroid-binding