Names & Taxonomy
- Uniprot ID:
- P04181
- Entry Name:
- OAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]
- Gene Names:
- OAT
- Gene Names Primary:
- OAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 439
- Sequence:
- MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Pathway:
- Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
- Catalytic Activity:
- L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00129
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
identical protein binding
ornithine-oxo-acid transaminase activity
pyridoxal phosphate binding
arginine catabolic process to glutamate
arginine catabolic process to proline via ornithine
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-proline biosynthetic process
protein hexamerization
small molecule metabolic process
visual perception - Gene Ontology Biological Process:
- arginine catabolic process to glutamate
arginine catabolic process to proline via ornithine
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-proline biosynthetic process
protein hexamerization
small molecule metabolic process
visual perception - Gene Ontology Molecular Function:
- identical protein binding
ornithine-oxo-acid transaminase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Aminotransferase
Complete proteome
Direct protein sequencing
Disease mutation
Mitochondrion
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
Transit peptide