Names & Taxonomy
- Uniprot ID:
- P04150
- Entry Name:
- GCR_HUMAN
- Status:
- reviewed
- Protein Names:
- Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
- Gene Names:
- NR3C1 GRL
- Gene Names Primary:
- NR3C1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 777
- Sequence:
- MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Alpha: Cytoplasm
Function
- Function:
- Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
- Cross Reference Drug Bank:
- DB00240 DB00288 DB00394 DB00443 DB01222 DB01410 DB01013 DB00838 DB01380 DB01260 DB00547 DB01234 DB00223 DB06781 DB00687 DB00663 DB00180 DB00591 DB01047 DB00324 DB01185 DB00846 DB08906 DB00588 DB00596 DB00769 DB00741 DB00873 DB00253 DB00351 DB00959 DB00834 DB00764 DB01384 DB01130 DB00860 DB00635 DB00896 DB00421 DB00620 DB08867
- Gene Ontology Go:
- cytoplasm
mitochondrial matrix
nucleoplasm
nucleus
glucocorticoid receptor activity
glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
steroid binding
steroid hormone binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
cellular response to steroid hormone stimulus
chromatin modification
gene expression
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
signal transduction
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated - Gene Ontology Biological Process:
- cellular response to steroid hormone stimulus
chromatin modification
gene expression
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
signal transduction
transcription, DNA-templated
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
glucocorticoid receptor activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
steroid binding
steroid hormone binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
mitochondrial matrix
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative initiation
Alternative splicing
Apoptosis
Cell cycle
Cell division
Chromatin regulator
Chromosome partition
Complete proteome
Cytoplasm
Cytoskeleton
DNA-binding
Disease mutation
Isopeptide bond
Lipid-binding
Metal-binding
Mitochondrion
Mitosis
Nucleus
Phosphoprotein
Polymorphism
Pseudohermaphroditism
RNA-binding
Receptor
Reference proteome
Steroid-binding
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- P31749; P59598; Q03135; P01730; P00533; P41235; P07900; Q6ZU52; P06239; Q62667; P82094
Publication
- PubMed ID:
- 2867473 1707881 20843780 17404046 21701417 17974005 15372022 15489334 2026589 1958537 3841189 8358712 7769088 8621628 9154805 9590696 10477749 10566686 10902803 10866662 10639135 11358809 11555652 11238589 11435610 11381138 12144530 12000743 12415108 15265776 15211577 15866175 15591535 15941832 16478993 16964243 18838540 18691976 18483179 18669648 19248771 19141540 19690332 20484466 20068231 21269460 21664385 21730050 22170608 21980503 22814378 23303127 23508108 23820903 24275569 26711253 25775514 25847991 12151000 12686538 1704018 8358735 8445027 7683692 8316249 9150737 10391209 10898924 11589680 11344238 11701741 12351458 11932321 12050230 15276593 15292341 15769988 16030164 17635946 20335448 21362280 23426617 24483153 26031419 26541474