Names & Taxonomy

Uniprot ID:
P04118
Entry Name:
COL_HUMAN
Status:
reviewed
Protein Names:
Colipase
Gene Names:
CLPS
Gene Names Primary:
CLPS
Organism:
Homo sapiens (Human)

Structure

Length:
112
Sequence:
MEKILILLLVALSVAYAAPGPRGIIINLENGELCMNSAQCKSNCCQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.; Enterostatin has a biological activity as a satiety signal.
Gene Ontology Go:
extracellular exosome
extracellular region
enzyme activator activity
fat-soluble vitamin metabolic process
lipid catabolic process
lipid digestion
lipid metabolic process
phototransduction, visible light
post-embryonic development
response to food
retinoid metabolic process
small molecule metabolic process
vitamin metabolic process
Gene Ontology Biological Process:
fat-soluble vitamin metabolic process
lipid catabolic process
lipid digestion
lipid metabolic process
phototransduction, visible light
post-embryonic development
response to food
retinoid metabolic process
small molecule metabolic process
vitamin metabolic process
Gene Ontology Molecular Function:
enzyme activator activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
Keywords:
Complete proteome
Diabetes mellitus
Digestion
Direct protein sequencing
Disulfide bond
Lipid degradation
Lipid metabolism
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
2337598 1643046 14574404 15489334 6691986 8479519 16189801