Names & Taxonomy
- Uniprot ID:
- P04040
- Entry Name:
- CATA_HUMAN
- Status:
- reviewed
- Protein Names:
- Catalase (EC 1.11.1.6)
- Gene Names:
- CAT
- Gene Names Primary:
- CAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 527
- Sequence:
- MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome.
Function
- Function:
- Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
- Catalytic Activity:
- 2 H(2)O(2) = O(2) + 2 H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; ; COFACTOR: Name=NADP(+); Xref=ChEBI:CHEBI:58349;
- Active Site:
- ACT_SITE 75 75; ACT_SITE 148 148
- Cross Reference Drug Bank:
- DB01213
- Gene Ontology Go:
- cytosol
endoplasmic reticulum
extracellular exosome
extracellular space
focal adhesion
Golgi apparatus
intracellular membrane-bounded organelle
lysosome
membrane
mitochondrial intermembrane space
mitochondrion
peroxisomal matrix
peroxisomal membrane
peroxisome
plasma membrane
aminoacylase activity
antioxidant activity
catalase activity
enzyme binding
heme binding
metal ion binding
NADP binding
oxidoreductase activity, acting on peroxide as acceptor
protein homodimerization activity
receptor binding
aerobic respiration
aging
cellular oxidant detoxification
cellular response to growth factor stimulus
cholesterol metabolic process
hemoglobin metabolic process
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of NF-kappaB transcription factor activity
nucleobase-containing small molecule metabolic process
osteoblast differentiation
positive regulation of cell division
positive regulation of NF-kappaB transcription factor activity
positive regulation of phosphatidylinositol 3-kinase signaling
protein homotetramerization
protein tetramerization
purine nucleobase metabolic process
purine nucleotide catabolic process
response to activity
response to cadmium ion
response to drug
response to estradiol
response to ethanol
response to fatty acid
response to hydrogen peroxide
response to hyperoxia
response to hypoxia
response to inactivity
response to insulin
response to L-ascorbic acid
response to lead ion
response to light intensity
response to ozone
response to phenylpropanoid
response to reactive oxygen species
response to vitamin A
response to vitamin E
small molecule metabolic process
triglyceride metabolic process
ureteric bud development
UV protection - Gene Ontology Biological Process:
- aerobic respiration
aging
cellular oxidant detoxification
cellular response to growth factor stimulus
cholesterol metabolic process
hemoglobin metabolic process
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of NF-kappaB transcription factor activity
nucleobase-containing small molecule metabolic process
osteoblast differentiation
positive regulation of cell division
positive regulation of NF-kappaB transcription factor activity
positive regulation of phosphatidylinositol 3-kinase signaling
protein homotetramerization
protein tetramerization
purine nucleobase metabolic process
purine nucleotide catabolic process
response to activity
response to cadmium ion
response to drug
response to estradiol
response to ethanol
response to fatty acid
response to hydrogen peroxide
response to hyperoxia
response to hypoxia
response to inactivity
response to insulin
response to L-ascorbic acid
response to lead ion
response to light intensity
response to ozone
response to phenylpropanoid
response to reactive oxygen species
response to vitamin A
response to vitamin E
small molecule metabolic process
triglyceride metabolic process
ureteric bud development
UV protection - Gene Ontology Molecular Function:
- aminoacylase activity
antioxidant activity
catalase activity
enzyme binding
heme binding
metal ion binding
NADP binding
oxidoreductase activity, acting on peroxide as acceptor
protein homodimerization activity
receptor binding - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum
extracellular exosome
extracellular space
focal adhesion
Golgi apparatus
intracellular membrane-bounded organelle
lysosome
membrane
mitochondrial intermembrane space
mitochondrion
peroxisomal matrix
peroxisomal membrane
peroxisome
plasma membrane - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Heme
Hydrogen peroxide
Iron
Metal-binding
Mitogen
NADP
Oxidoreductase
Peroxidase
Peroxisome
Phosphoprotein
Reference proteome