Names & Taxonomy
- Uniprot ID:
- P04003
- Entry Name:
- C4BPA_HUMAN
- Status:
- reviewed
- Protein Names:
- C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP)
- Gene Names:
- C4BPA C4BP
- Gene Names Primary:
- C4BPA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 597
- Sequence:
- MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
- Gene Ontology Go:
- blood microparticle
extracellular region
extracellular space
other organism cell
plasma membrane
poly(A) RNA binding
complement activation, classical pathway
innate immune response
negative regulation of complement activation, classical pathway
positive regulation of protein catabolic process
regulation of complement activation
regulation of opsonization - Gene Ontology Biological Process:
- complement activation, classical pathway
innate immune response
negative regulation of complement activation, classical pathway
positive regulation of protein catabolic process
regulation of complement activation
regulation of opsonization - Gene Ontology Molecular Function:
- poly(A) RNA binding
- Gene Ontology Cellular Component:
- blood microparticle
extracellular region
extracellular space
other organism cell
plasma membrane - Keywords:
- 3D-structure
Complement pathway
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity
Innate immunity
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Sushi - Interacts With:
- P13050