Names & Taxonomy
- Uniprot ID:
- P03952
- Entry Name:
- KLKB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
- Gene Names:
- KLKB1 KLK3
- Gene Names Primary:
- KLKB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 638
- Sequence:
- MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
- Catalytic Activity:
- Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by SERPINA5.
- Active Site:
- ACT_SITE 434 434 Charge relay system.; ACT_SITE 483 483 Charge relay system.; ACT_SITE 578 578 Charge relay system.
- Cross Reference Drug Bank:
- DB05311
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
plasma membrane
serine-type endopeptidase activity
blood coagulation
blood coagulation, intrinsic pathway
extracellular matrix disassembly
extracellular matrix organization
Factor XII activation
fibrinolysis
liver regeneration
plasminogen activation
positive regulation of fibrinolysis
proteolysis
zymogen activation - Gene Ontology Biological Process:
- blood coagulation
blood coagulation, intrinsic pathway
extracellular matrix disassembly
extracellular matrix organization
Factor XII activation
fibrinolysis
liver regeneration
plasminogen activation
positive regulation of fibrinolysis
proteolysis
zymogen activation - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
- Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
plasma membrane - Keywords:
- 3D-structure
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Fibrinolysis
Glycoprotein
Hemostasis
Hydrolase
Inflammatory response
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen