Names & Taxonomy

Uniprot ID:
P03952
Entry Name:
KLKB1_HUMAN
Status:
reviewed
Protein Names:
Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
Gene Names:
KLKB1 KLK3
Gene Names Primary:
KLKB1
Organism:
Homo sapiens (Human)

Structure

Length:
638
Sequence:
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Catalytic Activity:
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by SERPINA5.
Active Site:
ACT_SITE 434 434 Charge relay system.; ACT_SITE 483 483 Charge relay system.; ACT_SITE 578 578 Charge relay system.
Cross Reference Drug Bank:
DB05311
Gene Ontology Go:
extracellular exosome
extracellular region
extracellular space
plasma membrane
serine-type endopeptidase activity
blood coagulation
blood coagulation, intrinsic pathway
extracellular matrix disassembly
extracellular matrix organization
Factor XII activation
fibrinolysis
liver regeneration
plasminogen activation
positive regulation of fibrinolysis
proteolysis
zymogen activation
Gene Ontology Biological Process:
blood coagulation
blood coagulation, intrinsic pathway
extracellular matrix disassembly
extracellular matrix organization
Factor XII activation
fibrinolysis
liver regeneration
plasminogen activation
positive regulation of fibrinolysis
proteolysis
zymogen activation
Gene Ontology Molecular Function:
serine-type endopeptidase activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
extracellular space
plasma membrane
Keywords:
3D-structure
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Fibrinolysis
Glycoprotein
Hemostasis
Hydrolase
Inflammatory response
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Publication

PubMed ID:
3521732 11031105 14702039 15815621 15489334 1998666 2844223 12754519 16335952 19159218 14652634 17598838