Names & Taxonomy
- Uniprot ID:
- P03951
- Entry Name:
- FA11_HUMAN
- Status:
- reviewed
- Protein Names:
- Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
- Gene Names:
- F11
- Gene Names Primary:
- F11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 625
- Sequence:
- MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
- Catalytic Activity:
- Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by SERPINA5.
- Active Site:
- ACT_SITE 431 431 Charge relay system.; ACT_SITE 480 480 Charge relay system.; ACT_SITE 575 575 Charge relay system.
- Cross Reference Drug Bank:
- DB00100
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
membrane
plasma membrane
heparin binding
serine-type aminopeptidase activity
serine-type endopeptidase activity
blood coagulation
blood coagulation, intrinsic pathway
plasminogen activation
positive regulation of fibrinolysis - Gene Ontology Biological Process:
- blood coagulation
blood coagulation, intrinsic pathway
plasminogen activation
positive regulation of fibrinolysis - Gene Ontology Molecular Function:
- heparin binding
serine-type aminopeptidase activity
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Heparin-binding
Hydrolase
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal - Interacts With:
- P23827