Names & Taxonomy
- Uniprot ID:
- P03372
- Entry Name:
- ESR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
- Gene Names:
- ESR1 ESR NR3A1
- Gene Names Primary:
- ESR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 595
- Sequence:
- MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Nucleus
Function
- Function:
- Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
- Cross Reference Drug Bank:
- DB01431 DB06401 DB00882 DB00286 DB01406 DB00304 DB00890 DB00255 DB00783 DB01196 DB04573 DB00655 DB04574 DB00977 DB00823 DB00294 DB01185 DB00947 DB00367 DB00603 DB01065 DB01357 DB01183 DB00957 DB04938 DB00396 DB04575 DB00481 DB00675 DB00539 DB01108
- Gene Ontology Go:
- cytoplasm
Golgi apparatus
integral component of membrane
membrane
mitochondrion
nuclear chromatin
nucleoplasm
nucleus
perikaryon
perinuclear region of cytoplasm
plasma membrane
protein complex
T-tubule
terminal bouton
transcriptionally active chromatin
ATPase binding
beta-catenin binding
chromatin binding
core promoter sequence-specific DNA binding
enzyme binding
estrogen receptor activity
estrogen response element binding
hormone binding
identical protein binding
nitric-oxide synthase regulator activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
androgen metabolic process
antral ovarian follicle growth
baculum development
cellular response to estradiol stimulus
chromatin remodeling
decidualization
epithelial cell proliferation involved in mammary gland duct elongation
gene expression
intracellular estrogen receptor signaling pathway
intracellular steroid hormone receptor signaling pathway
mammary gland alveolus development
mammary gland branching involved in pregnancy
negative regulation of gene expression
negative regulation of glucose import
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron death
negative regulation of production of miRNAs involved in gene silencing by miRNA
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of smooth muscle cell proliferation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of triglyceride metabolic process
osteoblast development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of epithelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of fibroblast proliferation
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric-oxide synthase activity
positive regulation of phospholipase C activity
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
prostate epithelial cord elongation
protein localization to chromatin
regulation of branching involved in prostate gland morphogenesis
regulation of neuron apoptotic process
regulation of transcription, DNA-templated
response to estradiol
response to estrogen
Sertoli cell development
Sertoli cell proliferation
signal transduction
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
uterus development
vagina development - Gene Ontology Biological Process:
- androgen metabolic process
antral ovarian follicle growth
baculum development
cellular response to estradiol stimulus
chromatin remodeling
decidualization
epithelial cell proliferation involved in mammary gland duct elongation
gene expression
intracellular estrogen receptor signaling pathway
intracellular steroid hormone receptor signaling pathway
mammary gland alveolus development
mammary gland branching involved in pregnancy
negative regulation of gene expression
negative regulation of glucose import
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron death
negative regulation of production of miRNAs involved in gene silencing by miRNA
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of smooth muscle cell proliferation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of triglyceride metabolic process
osteoblast development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of epithelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of fibroblast proliferation
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric-oxide synthase activity
positive regulation of phospholipase C activity
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
prostate epithelial cord elongation
protein localization to chromatin
regulation of branching involved in prostate gland morphogenesis
regulation of neuron apoptotic process
regulation of transcription, DNA-templated
response to estradiol
response to estrogen
Sertoli cell development
Sertoli cell proliferation
signal transduction
transcription, DNA-templated
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
uterus development
vagina development - Gene Ontology Molecular Function:
- ATPase binding
beta-catenin binding
chromatin binding
core promoter sequence-specific DNA binding
enzyme binding
estrogen receptor activity
estrogen response element binding
hormone binding
identical protein binding
nitric-oxide synthase regulator activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
Golgi apparatus
integral component of membrane
membrane
mitochondrion
nuclear chromatin
nucleoplasm
nucleus
perikaryon
perinuclear region of cytoplasm
plasma membrane
protein complex
terminal bouton
transcriptionally active chromatin
T-tubule - Keywords:
- 3D-structure
Activator
Alternative promoter usage
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Disease mutation
Glycoprotein
Golgi apparatus
Lipid-binding
Lipoprotein
Membrane
Metal-binding
Methylation
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Steroid-binding
Transcription
Transcription regulation
Transmembrane
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- Itself; Q12802; Q9Y294; Q8IXJ9; P59598; P62952; P38398; P20290-2; Q86Y37; Q99966; Q9H467; Q92841; P17844; O00429; P00533; Q09472; Q12778; Q9Y3R0; O00165; P05627; O15054; O14686; Q9BQ69; Q00987; Q13330; O94776; Q9BTC8; P60660; Q15788; Q15596; Q9Y6Q9; Q9JLI4; Q9UN36; P19838; Q96RI1-3; Q9BTK6; Q96AQ6; P62962; Q99623; P27986; P53041; P55345; P60763; O43251; Q04206; Q14151; Q96HI0; P29353; P51532; P08047; Q02447; P12931; Q16881-4; Q8N895
Publication
- PubMed ID:
- 3754034 3753802 8600466 17974005 16165085 14574404 15489334 7476978 10619354 7916651 7539106 1577818 7838153 7651415 10409727 10970861 11075817 12554772 12682286 8999954 9328340 9627117 10428798 10567404 10359819 11265755 10681512 10816575 11581164 11477071 11358960 11113208 11682626 12039952 12093804 11971969 11875103 12415108 12917342 15047147 15078875 15199063 14764652 16043358 15891768 15940264 16603732 16684779 16427018 17085477 16617102 17043237 17658481 17347654 17914104 17006958 17587566 17505058 17311814 17998543 18247370 18657504 17932106 17922032 18563714 19712589 19117995 19423554 19350539 19383985 19339517 19718048 19636373 20074560 20705611 20720010 21104395 21937726 21330404 21602804 22031296 22083956 23160374 23874500 25219498 2247153 8221895 9338790 9600906 9875847 9619507 2792078 8961262 9195227 10942433 19749156 17224074 23841731