Names & Taxonomy
- Uniprot ID:
- P02792
- Entry Name:
- FRIL_HUMAN
- Status:
- reviewed
- Protein Names:
- Ferritin light chain (Ferritin L subunit)
- Gene Names:
- FTL
- Gene Names Primary:
- FTL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 175
- Sequence:
- MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
- Proteomes:
- UP000005640
Function
- Function:
- Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
- Cross Reference Drug Bank:
- DB00893
- Gene Ontology Go:
- cytosol
extracellular exosome
intracellular ferritin complex
membrane
ferric iron binding
identical protein binding
iron ion binding
cellular iron ion homeostasis
iron ion homeostasis
iron ion transport
membrane organization
post-Golgi vesicle-mediated transport
receptor-mediated endocytosis
transmembrane transport - Gene Ontology Biological Process:
- cellular iron ion homeostasis
iron ion homeostasis
iron ion transport
membrane organization
post-Golgi vesicle-mediated transport
receptor-mediated endocytosis
transmembrane transport - Gene Ontology Molecular Function:
- ferric iron binding
identical protein binding
iron ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
intracellular ferritin complex
membrane - Keywords:
- 3D-structure
Acetylation
Cataract
Complete proteome
Direct protein sequencing
Disease mutation
Iron
Iron storage
Metal-binding
Neurodegeneration
Reference proteome - Interacts With:
- Itself; P02794; Q6NZ44; P42858; Q8IYQ9; P15173; P43490; Q9NZ42; O00560; Q8N6Y0