Names & Taxonomy

Uniprot ID:
P02775
Entry Name:
CXCL7_HUMAN
Status:
reviewed
Protein Names:
Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
Gene Names:
PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1
Gene Names Primary:
PPBP
Organism:
Homo sapiens (Human)

Structure

Length:
128
Sequence:
MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.
Gene Ontology Go:
extracellular region
extracellular space
platelet alpha granule lumen
chemokine activity
CXCR chemokine receptor binding
glucose transmembrane transporter activity
blood coagulation
chemokine-mediated signaling pathway
defense response to bacterium
G-protein coupled receptor signaling pathway
glucose transmembrane transport
glucose transport
immune response
inflammatory response
leukocyte migration involved in inflammatory response
neutrophil chemotaxis
neutrophil degranulation
platelet activation
platelet degranulation
positive regulation of cell division
positive regulation of leukocyte chemotaxis
regulation of cell proliferation
response to lipopolysaccharide
Gene Ontology Biological Process:
blood coagulation
chemokine-mediated signaling pathway
defense response to bacterium
glucose transmembrane transport
glucose transport
G-protein coupled receptor signaling pathway
immune response
inflammatory response
leukocyte migration involved in inflammatory response
neutrophil chemotaxis
neutrophil degranulation
platelet activation
platelet degranulation
positive regulation of cell division
positive regulation of leukocyte chemotaxis
regulation of cell proliferation
response to lipopolysaccharide
Gene Ontology Molecular Function:
chemokine activity
CXCR chemokine receptor binding
glucose transmembrane transporter activity
Gene Ontology Cellular Component:
extracellular region
extracellular space
platelet alpha granule lumen
Keywords:
3D-structure
Antibiotic
Antimicrobial
Chemotaxis
Cleavage on pair of basic residues
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Growth factor
Mitogen
Reference proteome
Secreted
Signal

Publication

PubMed ID:
2713489 1826003 11468158 14702039 15815621 15489334 2423119 15340161 10877842 6572368 12665801 77677 8950790 2783111 2522778 7890771 2406364 2007144 9794434 24275569 8034022 7706245