Names & Taxonomy
- Uniprot ID:
- P02760
- Entry Name:
- AMBP_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein AMBP [Cleaved into: Alpha-1-microglobulin (Protein HC) (Alpha-1 microglycoprotein) (Complex-forming glycoprotein heterogeneous in charge); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (EDC1) (HI-30) (Uronic-acid-rich protein); Trypstatin]
- Gene Names:
- AMBP HCP ITIL
- Gene Names Primary:
- AMBP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 352
- Sequence:
- MRSLGALLLLLSACLAVSAGPVPTPPDNIQVQENFNISRIYGKWYNLAIGSTCPWLKKIMDRMTVSTLVLGEGATEAEISMTSTRWRKGVCEETSGAYEKTDTDGKFLYHKSKWNITMESYVVHTNYDEYAIFLTKKFSRHHGPTITAKLYGRAPQLRETLLQDFRVVAQGVGIPEDSIFTMADRGECVPGEQEPEPILIPRVRRAVLPQEEEGSGGGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNNFVTEKECLQTCRTVAACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCGVPGDGDEELLRFSN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
- Cross Reference Drug Bank:
- DB00062 DB00064
- Gene Ontology Go:
- blood microparticle
cell surface
extracellular exosome
extracellular region
extracellular space
intracellular membrane-bounded organelle
plasma membrane
calcium channel inhibitor activity
calcium oxalate binding
heme binding
IgA binding
protein homodimerization activity
serine-type endopeptidase inhibitor activity
small molecule binding
cell adhesion
female pregnancy
heme catabolic process
negative regulation of immune response
negative regulation of JNK cascade
protein catabolic process
protein-chromophore linkage
receptor-mediated endocytosis
viral process - Gene Ontology Biological Process:
- cell adhesion
female pregnancy
heme catabolic process
negative regulation of immune response
negative regulation of JNK cascade
protein catabolic process
protein-chromophore linkage
receptor-mediated endocytosis
viral process - Gene Ontology Molecular Function:
- calcium channel inhibitor activity
calcium oxalate binding
heme binding
IgA binding
protein homodimerization activity
serine-type endopeptidase inhibitor activity
small molecule binding - Gene Ontology Cellular Component:
- blood microparticle
cell surface
extracellular exosome
extracellular region
extracellular space
intracellular membrane-bounded organelle
plasma membrane - Keywords:
- 3D-structure
Chromophore
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Protease inhibitor
Reference proteome
Repeat
Secreted
Serine protease inhibitor
Signal - Interacts With:
- P07858; Q13643