Names & Taxonomy
- Uniprot ID:
- P02751
- Entry Name:
- FINC_HUMAN
- Status:
- reviewed
- Protein Names:
- Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
- Gene Names:
- FN1 FN
- Gene Names Primary:
- FN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2386
- Sequence:
- MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYPHGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNVIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.; Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
- Cross Reference Drug Bank:
- DB08888
- Gene Ontology Go:
- apical plasma membrane
basal lamina
blood microparticle
endoplasmic reticulum-Golgi intermediate compartment
extracellular exosome
extracellular matrix
extracellular region
extracellular space
fibrinogen complex
platelet alpha granule lumen
collagen binding
heparin binding
identical protein binding
integrin binding
mercury ion binding
peptidase activator activity
protease binding
acute-phase response
angiogenesis
blood coagulation
calcium-independent cell-matrix adhesion
cell adhesion
cell-substrate junction assembly
cellular response to BMP stimulus
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to lipopolysaccharide
cellular response to mercury ion
cellular response to platelet-derived growth factor stimulus
cellular response to prostaglandin E stimulus
cellular response to transforming growth factor beta stimulus
cellular response to vascular endothelial growth factor stimulus
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
glial cell migration
integrin activation
leukocyte migration
negative regulation of apoptotic process
negative regulation of transforming growth factor-beta secretion
peptide cross-linking
platelet activation
platelet degranulation
positive regulation of axon extension
positive regulation of cell proliferation
positive regulation of chemotaxis
positive regulation of fibroblast proliferation
positive regulation of gene expression
positive regulation of substrate-dependent cell migration, cell attachment to substrate
regulation of cell shape
regulation of ERK1 and ERK2 cascade
regulation of protein phosphorylation
response to glucocorticoid
response to ischemia
response to ozone
response to wounding
substrate adhesion-dependent cell spreading - Gene Ontology Biological Process:
- acute-phase response
angiogenesis
blood coagulation
calcium-independent cell-matrix adhesion
cell adhesion
cell-substrate junction assembly
cellular response to BMP stimulus
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to lipopolysaccharide
cellular response to mercury ion
cellular response to platelet-derived growth factor stimulus
cellular response to prostaglandin E stimulus
cellular response to transforming growth factor beta stimulus
cellular response to vascular endothelial growth factor stimulus
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
glial cell migration
integrin activation
leukocyte migration
negative regulation of apoptotic process
negative regulation of transforming growth factor-beta secretion
peptide cross-linking
platelet activation
platelet degranulation
positive regulation of axon extension
positive regulation of cell proliferation
positive regulation of chemotaxis
positive regulation of fibroblast proliferation
positive regulation of gene expression
positive regulation of substrate-dependent cell migration, cell attachment to substrate
regulation of cell shape
regulation of ERK1 and ERK2 cascade
regulation of protein phosphorylation
response to glucocorticoid
response to ischemia
response to ozone
response to wounding
substrate adhesion-dependent cell spreading - Gene Ontology Molecular Function:
- collagen binding
heparin binding
identical protein binding
integrin binding
mercury ion binding
peptidase activator activity
protease binding - Gene Ontology Cellular Component:
- apical plasma membrane
basal lamina
blood microparticle
endoplasmic reticulum-Golgi intermediate compartment
extracellular exosome
extracellular matrix
extracellular region
extracellular space
fibrinogen complex
platelet alpha granule lumen - Keywords:
- 3D-structure
Acute phase
Alternative splicing
Angiogenesis
Cell adhesion
Cell shape
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein
Heparin-binding
Isopeptide bond
Phosphoprotein
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Repeat
Secreted
Signal
Sulfation - Interacts With:
- Itself; Q99IB8; P29279; P35555; P35556; P14738; Q53682; Q93ED6; P06241; P08519; Q9CKF6; P11684; P21980; Q9UMX0; P40337
Publication
- PubMed ID:
- 11737888 16322219 16106752 17974005 15815621 15489334 3770189 3031656 2992939 6630202 3024962 3900070 17614963 6462919 3375063 2822387 3478690 7050098 6688418 3003095 3593230 2992573 2012601 6200322 3021206 12127832 2989004 3770201 4019516 6304699 2414772 3584091 1400330 7989369 8114919 9501082 11209058 11956183 12225811 11773026 14760718 15665290 16037490 16335952 17081983 16336961 18318008 19159218 19139490 19379667 22905912 24275569 26091039 1311202 1423622 8308892 7583666 9514732 10196121 10647176 11285216 11775745 12946358 12736686 8120888 8548820 10075919 14657397 17464288 17368672 18713862 19251642 16959974 18268355 21269460