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Names & Taxonomy

Uniprot ID:: P02730
Entry Name:: B3AT_HUMAN
Status:: reviewed
Protein Names:: Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233)
Gene Names:: SLC4A1 AE1 DI EPB3
Gene Names Primary:: SLC4A1
Organism:: Homo sapiens (Human)

Structure

Length:: 911
Sequence:: MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cell membrane
Intramembrane:: INTRAMEM 839 869 Discontinuously helical.

Function

Function:: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
Enzyme Regulation:: ENZYME REGULATION: Phenyl isothiocyanate inhibits anion transport in vitro.
Gene Ontology Go:: basolateral plasma membrane
blood microparticle
cortical cytoskeleton
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
Z disc
anion transmembrane transporter activity
anion:anion antiporter activity
ankyrin binding
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
inorganic anion exchanger activity
protein anchor
protein homodimerization activity
anion transport
bicarbonate transport
cellular ion homeostasis
chloride transmembrane transport
chloride transport
ion transport
small molecule metabolic process
transmembrane transport
Gene Ontology Biological Process:: anion transport
bicarbonate transport
cellular ion homeostasis
chloride transmembrane transport
chloride transport
ion transport
small molecule metabolic process
transmembrane transport
Gene Ontology Molecular Function:: anion:anion antiporter activity
anion transmembrane transporter activity
ankyrin binding
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
inorganic anion exchanger activity
protein anchor
protein homodimerization activity
Gene Ontology Cellular Component:: basolateral plasma membrane
blood microparticle
cortical cytoskeleton
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
Z disc
Keywords:: 3D-structure
Acetylation
Alternative splicing
Anion exchange
Blood group antigen
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Elliptocytosis
Glycoprotein
Hereditary hemolytic anemia
Ion transport
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:: P05026

Names & Taxonomy

Structure

Subcellular location

Function

Publication