Names & Taxonomy
- Uniprot ID:
- P02675
- Entry Name:
- FIBB_HUMAN
- Status:
- reviewed
- Protein Names:
- Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]
- Gene Names:
- FGB
- Gene Names Primary:
- FGB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 491
- Sequence:
- MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
- Cross Reference Drug Bank:
- DB00364
- Gene Ontology Go:
- blood microparticle
cell cortex
cell surface
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
extracellular vesicle
fibrinogen complex
plasma membrane
platelet alpha granule
platelet alpha granule lumen
chaperone binding
structural molecule activity
adaptive immune response
blood coagulation
blood coagulation, fibrin clot formation
cell-matrix adhesion
cellular protein complex assembly
cellular response to interleukin-1
cellular response to leptin stimulus
extracellular matrix organization
fibrinolysis
induction of bacterial agglutination
innate immune response
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
plasminogen activation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of ERK1 and ERK2 cascade
positive regulation of exocytosis
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
positive regulation of protein secretion
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of vasoconstriction
protein polymerization
response to calcium ion
signal transduction - Gene Ontology Biological Process:
- adaptive immune response
blood coagulation
blood coagulation, fibrin clot formation
cell-matrix adhesion
cellular protein complex assembly
cellular response to interleukin-1
cellular response to leptin stimulus
extracellular matrix organization
fibrinolysis
induction of bacterial agglutination
innate immune response
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
plasminogen activation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of ERK1 and ERK2 cascade
positive regulation of exocytosis
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
positive regulation of protein secretion
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of vasoconstriction
protein polymerization
response to calcium ion
signal transduction - Gene Ontology Molecular Function:
- chaperone binding
structural molecule activity - Gene Ontology Cellular Component:
- blood microparticle
cell cortex
cell surface
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
extracellular vesicle
fibrinogen complex
plasma membrane
platelet alpha granule
platelet alpha granule lumen - Keywords:
- 3D-structure
Adaptive immunity
Blood coagulation
Coiled coil
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Immunity
Innate immunity
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal - Interacts With:
- P27958