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Names & Taxonomy

Uniprot ID:: P02671
Entry Name:: FIBA_HUMAN
Status:: reviewed
Protein Names:: Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]
Gene Names:: FGA
Gene Names Primary:: FGA
Organism:: Homo sapiens (Human)

Structure

Length:: 866
Sequence:: MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Secreted

Function

Function:: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Cross Reference Drug Bank:: DB00009 DB00029 DB00015 DB00364 DB00031
Gene Ontology Go:: blood microparticle
cell cortex
cell surface
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
extracellular vesicle
fibrinogen complex
plasma membrane
platelet alpha granule
platelet alpha granule lumen
rough endoplasmic reticulum
metal ion binding
structural molecule activity
acute-phase response
adaptive immune response
blood coagulation
blood coagulation, common pathway
blood coagulation, fibrin clot formation
cell-matrix adhesion
cellular protein complex assembly
cellular protein metabolic process
cellular response to granulocyte colony-stimulating factor
cellular response to interleukin-6
cellular response to organic cyclic compound
extracellular matrix organization
fibrinolysis
induction of bacterial agglutination
innate immune response
liver regeneration
negative regulation of blood coagulation, common pathway
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
plasminogen activation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of ERK1 and ERK2 cascade
positive regulation of exocytosis
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
positive regulation of protein secretion
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of vasoconstriction
protein complex assembly
protein polymerization
response to calcium ion
response to cycloheximide
response to estradiol
response to genistein
response to morphine
signal transduction
Gene Ontology Biological Process:: acute-phase response
adaptive immune response
blood coagulation
blood coagulation, common pathway
blood coagulation, fibrin clot formation
cell-matrix adhesion
cellular protein complex assembly
cellular protein metabolic process
cellular response to granulocyte colony-stimulating factor
cellular response to interleukin-6
cellular response to organic cyclic compound
extracellular matrix organization
fibrinolysis
induction of bacterial agglutination
innate immune response
liver regeneration
negative regulation of blood coagulation, common pathway
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
plasminogen activation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of ERK1 and ERK2 cascade
positive regulation of exocytosis
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
positive regulation of protein secretion
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of vasoconstriction
protein complex assembly
protein polymerization
response to calcium ion
response to cycloheximide
response to estradiol
response to genistein
response to morphine
signal transduction
Gene Ontology Molecular Function:: metal ion binding
structural molecule activity
Gene Ontology Cellular Component:: blood microparticle
cell cortex
cell surface
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
extracellular vesicle
fibrinogen complex
plasma membrane
platelet alpha granule
platelet alpha granule lumen
rough endoplasmic reticulum
Keywords:: 3D-structure
Adaptive immunity
Alternative splicing
Amyloid
Amyloidosis
Blood coagulation
Calcium
Coiled coil
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Hydroxylation
Immunity
Innate immunity
Isopeptide bond
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal
Interacts With:: P02647

Names & Taxonomy

Structure

Subcellular location

Function

Publication