Names & Taxonomy
- Uniprot ID:
- P02585
- Entry Name:
- TNNC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Troponin C, skeletal muscle
- Gene Names:
- TNNC2
- Gene Names Primary:
- TNNC2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 160
- Sequence:
- MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
- Proteomes:
- UP000005640
Function
- Function:
- Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
- Cross Reference Drug Bank:
- DB01023
- Gene Ontology Go:
- cytosol
troponin complex
calcium ion binding
muscle filament sliding
regulation of muscle contraction
skeletal muscle contraction - Gene Ontology Biological Process:
- muscle filament sliding
regulation of muscle contraction
skeletal muscle contraction - Gene Ontology Molecular Function:
- calcium ion binding
- Gene Ontology Cellular Component:
- cytosol
troponin complex - Keywords:
- Acetylation
Calcium
Complete proteome
Direct protein sequencing
Metal-binding
Muscle protein
Reference proteome
Repeat - Interacts With:
- Q6FGX2