Names & Taxonomy
- Uniprot ID:
- P01308
- Entry Name:
- INS_HUMAN
- Status:
- reviewed
- Protein Names:
- Insulin [Cleaved into: Insulin B chain; Insulin A chain]
- Gene Names:
- INS
- Gene Names Primary:
- INS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 110
- Sequence:
- MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
- Gene Ontology Go:
- endoplasmic reticulum lumen
endoplasmic reticulum-Golgi intermediate compartment membrane
endosome lumen
extracellular region
extracellular space
Golgi lumen
Golgi membrane
secretory granule lumen
transport vesicle
hormone activity
identical protein binding
insulin receptor binding
insulin-like growth factor receptor binding
protease binding
activation of protein kinase B activity
acute-phase response
alpha-beta T cell activation
cell-cell signaling
cellular protein metabolic process
endocrine pancreas development
energy reserve metabolic process
ER to Golgi vesicle-mediated transport
fatty acid homeostasis
G-protein coupled receptor signaling pathway
glucose homeostasis
glucose metabolic process
glucose transport
insulin receptor signaling pathway
MAPK cascade
membrane organization
negative regulation of acute inflammatory response
negative regulation of fatty acid metabolic process
negative regulation of feeding behavior
negative regulation of gluconeogenesis
negative regulation of glycogen catabolic process
negative regulation of lipid catabolic process
negative regulation of NAD(P)H oxidase activity
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of protein catabolic process
negative regulation of protein oligomerization
negative regulation of protein secretion
negative regulation of proteolysis
negative regulation of respiratory burst involved in inflammatory response
negative regulation of vasodilation
positive regulation of brown fat cell differentiation
positive regulation of cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cellular protein metabolic process
positive regulation of cytokine secretion
positive regulation of DNA replication
positive regulation of glucose import
positive regulation of glycogen biosynthetic process
positive regulation of glycolytic process
positive regulation of insulin receptor signaling pathway
positive regulation of lipid biosynthetic process
positive regulation of MAPK cascade
positive regulation of mitotic nuclear division
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric-oxide synthase activity
positive regulation of peptide hormone secretion
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein autophosphorylation
positive regulation of protein kinase B signaling
positive regulation of protein localization to nucleus
positive regulation of respiratory burst
positive regulation of vasodilation
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of cellular amino acid metabolic process
regulation of insulin secretion
regulation of protein localization
regulation of protein secretion
regulation of transcription, DNA-templated
regulation of transmembrane transporter activity
small molecule metabolic process
wound healing - Gene Ontology Biological Process:
- activation of protein kinase B activity
acute-phase response
alpha-beta T cell activation
cell-cell signaling
cellular protein metabolic process
endocrine pancreas development
energy reserve metabolic process
ER to Golgi vesicle-mediated transport
fatty acid homeostasis
glucose homeostasis
glucose metabolic process
glucose transport
G-protein coupled receptor signaling pathway
insulin receptor signaling pathway
MAPK cascade
membrane organization
negative regulation of acute inflammatory response
negative regulation of fatty acid metabolic process
negative regulation of feeding behavior
negative regulation of gluconeogenesis
negative regulation of glycogen catabolic process
negative regulation of lipid catabolic process
negative regulation of NAD(P)H oxidase activity
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of protein catabolic process
negative regulation of protein oligomerization
negative regulation of protein secretion
negative regulation of proteolysis
negative regulation of respiratory burst involved in inflammatory response
negative regulation of vasodilation
positive regulation of brown fat cell differentiation
positive regulation of cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cellular protein metabolic process
positive regulation of cytokine secretion
positive regulation of DNA replication
positive regulation of glucose import
positive regulation of glycogen biosynthetic process
positive regulation of glycolytic process
positive regulation of insulin receptor signaling pathway
positive regulation of lipid biosynthetic process
positive regulation of MAPK cascade
positive regulation of mitotic nuclear division
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric-oxide synthase activity
positive regulation of peptide hormone secretion
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein autophosphorylation
positive regulation of protein kinase B signaling
positive regulation of protein localization to nucleus
positive regulation of respiratory burst
positive regulation of vasodilation
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of cellular amino acid metabolic process
regulation of insulin secretion
regulation of protein localization
regulation of protein secretion
regulation of transcription, DNA-templated
regulation of transmembrane transporter activity
small molecule metabolic process
wound healing - Gene Ontology Molecular Function:
- hormone activity
identical protein binding
insulin-like growth factor receptor binding
insulin receptor binding
protease binding - Gene Ontology Cellular Component:
- endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum lumen
endosome lumen
extracellular region
extracellular space
Golgi lumen
Golgi membrane
secretory granule lumen
transport vesicle - Keywords:
- 3D-structure
Alternative splicing
Carbohydrate metabolism
Cleavage on pair of basic residues
Complete proteome
Diabetes mellitus
Direct protein sequencing
Disease mutation
Disulfide bond
Glucose metabolism
Hormone
Pharmaceutical
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- Itself