Names & Taxonomy
- Uniprot ID:
- P01130
- Entry Name:
- LDLR_HUMAN
- Status:
- reviewed
- Protein Names:
- Low-density lipoprotein receptor (LDL receptor)
- Gene Names:
- LDLR
- Gene Names Primary:
- LDLR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 860
- Sequence:
- MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.
Function
- Function:
- Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.; (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins (PubMed:10535997, PubMed:12615904). Acts as a receptor for vesicular stomatitis virus (PubMed:23589850). In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells (PubMed:11100124).
- Cross Reference Drug Bank:
- DB00707
- Gene Ontology Go:
- apical part of cell
basolateral plasma membrane
cell surface
clathrin-coated endocytic vesicle membrane
coated pit
early endosome
endosome membrane
external side of plasma membrane
Golgi apparatus
integral component of plasma membrane
late endosome
low-density lipoprotein particle
lysosome
membrane
PCSK9-LDLR complex
plasma membrane
receptor complex
calcium ion binding
clathrin heavy chain binding
glycoprotein binding
identical protein binding
low-density lipoprotein particle binding
low-density lipoprotein receptor activity
protease binding
receptor activity
very-low-density lipoprotein particle receptor activity
virus receptor activity
cholesterol homeostasis
cholesterol import
cholesterol metabolic process
cholesterol transport
endocytosis
fat-soluble vitamin metabolic process
intestinal cholesterol absorption
lipid metabolic process
lipoprotein catabolic process
lipoprotein metabolic process
low-density lipoprotein particle clearance
phospholipid transport
phototransduction, visible light
positive regulation of triglyceride biosynthetic process
receptor-mediated endocytosis
regulation of cholesterol homeostasis
regulation of phosphatidylcholine catabolic process
retinoid metabolic process
small molecule metabolic process
vitamin metabolic process - Gene Ontology Biological Process:
- cholesterol homeostasis
cholesterol import
cholesterol metabolic process
cholesterol transport
endocytosis
fat-soluble vitamin metabolic process
intestinal cholesterol absorption
lipid metabolic process
lipoprotein catabolic process
lipoprotein metabolic process
low-density lipoprotein particle clearance
phospholipid transport
phototransduction, visible light
positive regulation of triglyceride biosynthetic process
receptor-mediated endocytosis
regulation of cholesterol homeostasis
regulation of phosphatidylcholine catabolic process
retinoid metabolic process
small molecule metabolic process
vitamin metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
clathrin heavy chain binding
glycoprotein binding
identical protein binding
low-density lipoprotein particle binding
low-density lipoprotein receptor activity
protease binding
receptor activity
very-low-density lipoprotein particle receptor activity
virus receptor activity - Gene Ontology Cellular Component:
- apical part of cell
basolateral plasma membrane
cell surface
clathrin-coated endocytic vesicle membrane
coated pit
early endosome
endosome membrane
external side of plasma membrane
Golgi apparatus
integral component of plasma membrane
late endosome
low-density lipoprotein particle
lysosome
membrane
PCSK9-LDLR complex
plasma membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Cholesterol metabolism
Coated pit
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Golgi apparatus
Host cell receptor for virus entry
Host-virus interaction
LDL
Lipid metabolism
Lipid transport
Lysosome
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Steroid metabolism
Sterol metabolism
Transmembrane
Transmembrane helix
Transport
Ubl conjugation - Interacts With:
- Itself; P04114; P02649; Q8NBP7
Publication
- PubMed ID:
- 6091915 2988123 14702039 15057824 15489334 8127891 3005267 3104336 10535997 11100124 12221107 12944399 12754519 12615904 14739284 16335952 15592455 17461796 19159218 19520913 21269460 21149300 23589850 24275569 25944712 7603991 7578052 9262405 10933493 12459547 1301956 9016531 3263645 2569482 3955657 8347689 2318961 1446662 1867200 8462973 8168830 2726768 1464748 7573037 7583548 7550239 7635461 7635482 7649546 7649549 8740918 8664907 9026534 9254862 9143924 9259195 9104431 9654205 9452094 9452095 9452118 10206683 10660340 9852677 9678702 10532689 10422803 10090484 10447263 10391209 10978268 10980548 10882754 11298688 11462246 17142622 17347910 19318025 19319977 21418584 22160468 24529145 25545329 25378237